Argipressin Acetate | CAS 113-79-1 / 129979-57-3 | Vasopressin V1/V2 Receptor Agonist (Research Use Only) | Knowlux

Product Description

Argipressin Acetate, CAS 113-79-1 (arginine vasopressin free peptide) / 129979-57-3 (acetate salt), is a synthetic cyclic nonapeptide hormone corresponding to human arginine vasopressin (AVP, antidiuretic hormone), supplied by Knowlux for laboratory research use. The sequence is H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2, with a disulfide bridge between Cys1 and Cys6. The molecular formula is C46H65N15O12S2 and the molecular weight is 1084.23 g/mol (free peptide basis). Each lot is released with a lot-specific COA, MSDS and analytical traceability.

CAS and Salt Form Clarification: CAS 113-79-1 is the registry most commonly associated with Argipressin (arginine vasopressin), and supplier listings frequently apply this CAS to the acetate salt under the product name "Argipressin Acetate". The acetate salt form is also assigned CAS 129979-57-3 by some manufacturers, with a molecular formula of C48H69N15O14S2 (C46H65N15O12S2.2C2H4O2) and a molecular weight of approximately 1144.28 g/mol. A third registry, 83968-48-3, appears on some datasheets for a hydrate/salt form and should not be used without supplier confirmation. Knowlux declares the salt basis, acetate content, and water content per lot on the COA. Buyers should confirm whether the quoted material is the free peptide or the acetate salt before procurement, as the counter-ion and hydration state shift the mass balance by approximately 60 g/mol.

Sequence and Structural Verification: The 9-residue sequence H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 with a disulfide bridge between Cys1 and Cys6 is confirmed by ChemicalBook, MedChemExpress, Bachem, and PeptideDB. The C-terminus is glycinamide (Gly-NH2), amidated against carboxypeptidase degradation. The N-terminus is free cysteine. Argipressin differs from oxytocin in three residues (Phe3, Arg8, and the absence of the C-terminal extension) and is the endogenous human antidiuretic hormone.

Product Parameters

Product Details

1. Overview

Argipressin (arginine vasopressin, AVP) is a cyclic nonapeptide hormone secreted by the posterior pituitary that regulates water balance, vascular tone, and several central nervous system functions. It acts through three class A G protein-coupled receptor subtypes: V1a (vascular smooth muscle contraction), V1b (pituitary ACTH release), and V2 (renal water reabsorption via aquaporin-2). In clinical medicine, argipressin is used for central diabetes insipidus and vasodilatory shock. The material supplied under this specification is research-grade and is not intended for human administration. Knowlux supplies this compound strictly for laboratory investigation of vasopressin receptor pharmacology, water homeostasis, and cardiovascular signaling.

2. Receptor Pharmacology

Argipressin binds V1a, V1b, and V2 receptors with high affinity. Reported binding affinities (Ki) are 1.8 +/- 0.4 nM for V1a and approximately 0.85 nM for V2, with functional EC50 values of 0.17 +/- 0.02 nM (V1b) and 0.24 +/- 0.03 nM (V2) in recombinant assay systems. In A7r5 rat aortic smooth muscle cells, the V1 receptor Kd is 1.31 nM, and intracellular calcium release is stimulated with an EC50 of 5 nM. These values are assay- and system-dependent and are provided for scientific reference only. The peptide is non-selective across the three receptor subtypes under most experimental conditions, which distinguishes its pharmacological profile from subtype-selective analogues such as desmopressin (V2-preferring) and terlipressin (V1-preferring).

3. Research Applications

Published pharmacological characterizations describe the following research applications:

• V1a, V1b, and V2 receptor binding and functional assays (cAMP, calcium mobilization, aquaporin trafficking)

• Vascular smooth muscle contraction and blood pressure regulation studies

• Renal water reabsorption and antidiuretic mechanism research

• Central nervous system studies of AVP as a neuromodulator (learning, memory, social behavior)

• Reference standard development for HPLC and LC-MS analytical methods

These descriptions are derived from published research and are provided for scientific reference only. They do not constitute clinical guidance or dosing recommendations.

Quality Control

Solubility and Handling

Solubility: Argipressin Acetate is freely soluble in water, consistent with its highly basic character (pI ~10.0). Reported aqueous solubility varies by salt form and measurement condition: ChemicalBook lists >=360 mg/mL (332.03 mM) for the CAS 113-79-1 material; Biorbyt reports >=166.7 mg/mL (145.68 mM) for its acetate salt lot; Selleck lists 100 mg/mL in water and 100 mg/mL in DMSO (92.23 mM); and one Chinese supplier reports 70.71 mg/mL (61.79 mM) with sonication. The peptide is also soluble in physiological saline and weakly acidic buffers (pH 3-5 acetate buffer). For most assay formats, water or buffered saline is suitable; DMSO stock solutions are an alternative for water-sensitive assays. Prepare solutions fresh and aliquot to avoid repeated freeze-thaw cycles.

Handling Precautions: Use powder-handling containment (glove box or fume hood with particulate control). Avoid inhalation of fine powder. ChemicalBook assigns GHS07 (warning, H332, harmful if inhaled) for the CAS 113-79-1 material; consult the lot-specific MSDS for applicable handling guidance. Wear nitrile gloves, lab coat, and eye protection. The disulfide bridge is sensitive to reducing agents; avoid contact with dithiothreitol (DTT) or mercaptoethanol during handling.

Storage and Stability

Storage guidance varies among suppliers: InvivoChem and Selleck specify 3 years at -20C and 2 years at 4C for powder, with solutions stable for 6 months at -80C or 1 month at -20C. MedChemExpress specifies 2 years at -80C and 1 year at -20C for powder under nitrogen, with solutions stable for 1 year at -80C or 6 months at -20C. ChemicalBook lists 2-8C as the storage condition for the CAS 113-79-1 material. The lyophilized powder is hygroscopic; equilibrate vials to room temperature before opening to prevent condensation. Protect from light and moisture. Shipping is typically at ambient temperature, as multiple suppliers note the product is stable for a few days under ordinary shipping conditions.

Documentation Support

Per lot: COA, MSDS, certificate of origin, HPLC chromatogram, and mass spectrometry data. Acetate content, water content, and endotoxin data available on request. Custom specifications and third-party inspection can be arranged on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

FOR RESEARCH USE ONLY. NOT FOR HUMAN USE. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Argipressin is an approved medicinal product in certain jurisdictions for specific clinical indications; however, the material offered under this specification is research-grade and is not intended for clinical use. The purchaser is responsible for verifying product specifications against their specific research requirements and for compliance with all applicable institutional, local, and national regulations governing research chemical acquisition, storage, and use. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.

Data Verification Notes: The molecular formula C46H65N15O12S2 and molecular weight 1084.23 g/mol for the free peptide are confirmed across ChemicalBook, MedChemExpress, Bachem, and multiple Chinese supplier COAs. The sequence H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 with disulfide bridge Cys1-Cys6 is consistent across ChemicalBook, MedChemExpress, Bachem, and PeptideDB. The acetate salt registries 129979-57-3 (diacetate) and the hydrate/salt registry 83968-48-3 are noted; the C48H69N15O14S2 / 1144.28 g/mol assignment reflects the diacetate form and should not be applied to the free peptide CAS without clarification. Solubility values are reported with their source conditions rather than reconciled into a single figure because the measurements reflect different salt forms, hydration states, and dissolution techniques. Endotoxin specifications are supplier-dependent (<=5 EU/mg for the research-grade acetate); the applicable limit should be confirmed on the lot-specific COA.

Formatting Note: All formulas, sequences, and comparison operators use plain ASCII notation to prevent character corruption on the platform. Section headings, table alignment, and spacing follow the approved product detail pattern. No trailing spaces or non-breaking characters are used; tables use consistent pipe alignment.