Palmitoylethanolamide (PEA Micro) | CAS 544-31-0 | Fatty Acid Amide (Research Use Only) | Knowlux

Product Description

Palmitoylethanolamide (PEA Micro), CAS 544-31-0, is a synthetic fatty acid amide supplied by Knowlux for laboratory research use. It is also known as Palmidrol, N-(2-hydroxyethyl)hexadecanamide, or PEA, and belongs to the N-acylethanolamine family of endogenous lipid mediators. The Micro designation refers to a micronized grade with a controlled particle size distribution, which is used in research settings where dissolution rate or suspension uniformity matters. The molecular formula is C18H37NO2 and the molecular weight is 299.49 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Form and grade clarification: CAS 544-31-0 is consistently recorded across PubChem, ChemicalBook and GuideChem as the base PEA molecule. Commercial PEA is available in native, micronized and ultra-micronized grades, and the particle size distribution is a specification parameter rather than a different chemical entity. Knowlux supplies the micronized grade and reports the measured particle size distribution on the COA. Commercial listings frequently describe PEA as a dietary supplement ingredient or anti-inflammatory agent; those designations attach to compliant supplement-supply chains and do not apply to this research-grade lot.

Product Parameters

Product Details

1. Overview

Palmitoylethanolamide is an endogenous fatty acid amide belonging to the N-acylethanolamine family, structurally related to anandamide but lacking its psychoactive properties. It is biosynthesised from palmitic acid and ethanolamine and is present in various animal and plant tissues. The micronized grade is produced by jet milling or precipitation processes that reduce particle size, a modification intended to improve dissolution behaviour and oral bioavailability in research models. Knowlux supplies PEA Micro as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished supplement or drug product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes PEA as a fatty acid amide studied in in vitro and in vivo research models, with proposed interactions involving PPAR-alpha and other cellular targets. The micronized form has been investigated in preclinical models for differences in absorption and efficacy relative to native PEA. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of PEA Micro for pain relief, anti-inflammatory use, neuroprotection, or any therapeutic indication is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in PEA supply are rarely the assay itself. Residual free ethanolamine is a priority control because it is irritant and odorous and signals incomplete workup; residual palmitic acid indicates poor conversion; and undeclared O-acylated or diacylated by-products distort purity and performance. Buyers should require a specific chromatographic assay and a declared limit for free ethanolamine, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for PEA analytical method development

• In vitro fatty acid amide metabolism and transport studies

• PPAR-alpha signalling and lipid mediator pathway research

• Particle size and dissolution behaviour studies (micronized vs native PEA)

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. PEA has a melting point near 99 C; prolonged exposure to high container temperatures during transit can cause caking, so thermal protection is specified for tropical lanes. Cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, residual ethanolamine report, particle size distribution report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. PEA is sold as a food supplement in some jurisdictions, including Italy and Spain, but is not FDA-approved as a drug; those regulatory positions attach to compliant supplement-supply chains and do not apply to, and are not represented by, this research-grade lot. PEA is typically derived from vegetable palm oil; operators placing the material on the EU market should apply deforestation-free supply-chain due diligence under Regulation (EU) 2023/1115 where palm derivatives are in scope. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.