SANA (MVD1) | CAS 42571-07-3 | (E)-2-Hydroxy-5-(2-nitrovinyl)benzoic acid (Research Use Only) | Knowlux

Product Description

SANA (MVD1), CAS 42571-07-3, is a synthetic salicylic acid derivative supplied by Knowlux for laboratory research use. Its chemical name is (E)-2-hydroxy-5-(2-nitrovinyl)benzoic acid, and it is a nitroalkene-based small molecule featuring a salicylate scaffold with a trans-nitrovinyl group at the 5-position. The molecular formula is C9H7NO5 and the molecular weight is 209.16 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: CAS 42571-07-3 is consistently recorded across MedChemExpress, TargetMol and ChemicalBook as (E)-2-hydroxy-5-(2-nitrovinyl)benzoic acid, with the synonym SANA or MVD1. The compound is typically supplied as a yellow crystalline powder and is noted to be soluble in organic solvents such as ethanol and DMSO. Commercial listings describe SANA as a fat-reducing or weight-loss raw material; those designations attach to unregulated supplement markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

SANA is a nitroalkene derivative built on a salicylic acid scaffold. The molecule carries three reactive functional groups: a phenolic hydroxyl, a carboxylic acid, and a conjugated trans-nitrovinyl moiety. This combination makes it a versatile synthetic building block as well as a tool compound for metabolic research. It has been investigated as an orally active pleiotropic metabolic modulator in preclinical and early clinical settings. Knowlux supplies SANA as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug or supplement product.

2. Research Context (Not a Therapeutic Claim)

Published research describes SANA as a compound with multiple reported activities in in vitro and in vivo models. TargetMol's pharmacological summary notes that SANA inhibits NF-kappaB activation, activates Nrf2/Keap1 and AMPK pathways, suppresses inflammasome activity, and promotes thermogenesis in adipose tissue models. In macrophage studies, SANA (0.1 mM) inhibited LPS-induced NF-kappaB/p65 nuclear translocation and reduced IL-6, TNF-alpha and MCP-1 gene expression; in Hep G2 cells it induced Nrf2-dependent HO-1, GCLM and NQO1 expression. In vivo, oral SANA (100-400 mg/kg) dose-dependently activated hepatic AMPK in mice and prolonged skin allograft survival in a 16-day dosing model.

A supplier technical note further describes a creatine-dependent thermogenic mechanism in adipose tissue that is independent of UCP1, and references a 2025 Phase 1 clinical trial published in Nature Metabolism reporting safety and tolerability over 2 weeks with preliminary signals on weight and glucose management. These descriptions are derived from published research and supplier literature and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of SANA for fat loss, appetite suppression, weight management, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in SANA supply are related to residual starting materials from the synthesis (salicylic acid derivatives and nitroalkene precursors) and isomeric purity of the E-nitrovinyl group. Buyers should require a specific chromatographic assay and a declared limit for related substances, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for SANA analytical method development

• In vitro NF-kappaB, Nrf2/Keap1 and AMPK signalling pathway research

• Inflammasome activity and cytokine secretion studies

• Adipose thermogenesis and metabolic disease model research

• Synthetic building block for nitroalkene-derived compound libraries

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. SANA is an investigational compound and is not approved as a therapeutic product in any jurisdiction. Supplier listings describe early-phase clinical research on SANA; those findings are scientific background only and do not constitute marketing approval or a health claim. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.