Salmon Calcitonin | CAS 47931-85-1 | Calcitonin Receptor Agonist (Research Use Only) | Knowlux

Product Description

Salmon Calcitonin, CAS 47931-85-1, is a synthetic 32-amino-acid polypeptide hormone supplied by Knowlux for laboratory research use. The sequence is Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2, with a disulfide bridge between Cys1 and Cys7. The molecular formula is C145H240N44O48S2 and the molecular weight is 3431.85 g/mol (free peptide basis). Each lot is released with a lot-specific COA, MSDS and analytical traceability.

CAS and Salt Form Clarification: CAS 47931-85-1 is the established registry for Salmon Calcitonin free peptide. The acetate salt form is frequently listed under CAS 158000-61-4 in peptide databases. Supplier listings on ChemicalBook and GuideChem predominantly use 47931-85-1 regardless of salt form, which can cause ambiguity in specification comparison. Knowlux declares the counter-ion basis and acetate content per lot on the COA. Buyers should confirm whether the quoted material is free peptide or acetate salt before procurement.

Sequence Verification Note: One ChemicalBook supplier listing shows an incorrect C-terminal sequence ending in Met-Pro-Leu-Trp-Leu-NH2. The correct sequence, confirmed by GuideChem, PeptideDB, and KEGG, terminates in Thr-Pro-NH2. Buyers should verify the full sequence on the supplier COA before purchase.

Product Parameters

Product Details

1. Overview

Salmon Calcitonin is a synthetic polypeptide hormone corresponding to the calcitonin sequence found in salmon (Salmo salar). It is a 32-residue peptide characterized by a disulfide bridge between Cys1 and Cys7 and an amidated C-terminal proline. In research settings, it is used as a tool compound for studying calcium and phosphorus metabolism, bone resorption mechanisms, and calcitonin receptor (CTR/CALCR) signaling. While salmon calcitonin is an approved therapeutic agent in certain jurisdictions for conditions such as osteoporosis and hypercalcemia, the material supplied under this specification is research-grade and is not intended for human administration. Knowlux supplies this compound strictly for laboratory investigation.

2. Structural Profile

The peptide backbone comprises 32 amino acids with a disulfide bridge cyclising the N-terminal region between Cys1 and Cys7. The C-terminal proline is amidated, protecting against carboxypeptidase degradation. Salmon calcitonin differs from human calcitonin in several residues and is reported to exhibit higher receptor binding affinity and longer half-life in preclinical models. The disulfide bridge is essential for biological activity and is susceptible to reduction; handling procedures should avoid contact with reducing agents such as DTT or mercaptoethanol.

3. Research Applications

Published pharmacological characterizations describe the following research applications:

• Calcitonin receptor (CTR/CALCR) binding and functional assays

• Bone resorption and osteoclast activity studies

• Calcium and phosphorus metabolism research

• Reference standard development for HPLC and LC-MS analytical methods

• Formulation development for peptide delivery systems

These descriptions are derived from published research and are provided for scientific reference only. They do not constitute clinical guidance or dosing recommendations. The GuideChem supplier listing explicitly notes that research-grade Salmon Calcitonin is intended for bone metabolism pharmacology, osteoporosis, and hypercalcemia mechanism studies, and is not for direct human use.

Quality Control

Solubility and Handling

Solubility: Salmon Calcitonin is soluble in water. Supplier data for the acetate salt indicates aqueous solubility suitable for stock preparation. DMSO solubility is supplier-dependent and should be confirmed on the lot-specific technical sheet. Prepare solutions fresh and aliquot to avoid repeated freeze-thaw cycles.

Handling Precautions: Use powder-handling containment (glove box or fume hood with particulate control). Avoid inhalation of fine powder. Wear nitrile gloves, lab coat, and eye protection. Follow institutional chemical hygiene plans for research peptides. The disulfide bridge is sensitive to reducing agents; avoid DTT and mercaptoethanol during handling.

Storage and Stability

Documentation Support

Per lot: COA, MSDS, HPLC chromatogram, and mass spectrometry data. Sequence verification data and counter-ion specification available on request. Custom specifications and third-party inspection can be arranged on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

FOR RESEARCH USE ONLY. NOT FOR HUMAN USE. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Salmon Calcitonin is an approved medicinal product in certain jurisdictions for specific clinical indications; however, the material offered under this specification is research-grade and is not intended for clinical use. The purchaser is responsible for verifying product specifications against their specific research requirements and for compliance with all applicable institutional, local, and national regulations governing research chemical acquisition, storage, and use. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.