|
- Brand：Knowlux
- Model：Bottle/Drum/Customized to your needs
- Purity：99%+
- Cas：307297-39-8
- Createtime： 2026-11-13
- Updatetime： 2026-11-03
| Sample availble | Yes |
| useage | Laboratory research，Food/nutraceutical industry (regulated forms only)，Cosmetics |
| deliveryInfo | |
| appearance | White powder |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C14H22N4O9 |
Epitalon (Epithalon) | CAS 307297-39-8 | Tetrapeptide AEDG (Research Use Only) | Knowlux
Product Description
Epitalon (also spelled Epithalon), CAS 307297-39-8, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), supplied by Knowlux for laboratory research use. The peptide corresponds to the active fragment of Epithalamin, a polypeptide preparation originally derived from bovine pineal gland extract. The molecular formula is C14H22N4O9 and the molecular weight is 390.35 g/mol. Each lot is released with a lot-specific COA, MSDS and analytical traceability.
CAS and Naming Clarification: CAS 307297-39-8 is the established registry for Epitalon free peptide. Some supplier listings also reference CAS 307297-40-1 alongside the same product name; this appears to be a related registry and should not be used as the primary procurement identifier without supplier confirmation. The compound is also listed under the synonyms Epithalon, Epithalone, and AEDG. Buyers should verify that the COA states CAS 307297-39-8 and declares the counter-ion basis.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Epitalon (Epithalon) |
| Synonyms | Epithalon; Epithalone; AEDG; Ala-Glu-Asp-Gly |
| CAS No. | 307297-39-8 |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| Sequence (1-letter) | AEDG |
| Sequence (3-letter) | H-Ala-Glu-Asp-Gly-OH |
| Sequence Length | 4 amino acids, linear |
| Key Structural Features | Free N-terminal amine; free C-terminal carboxylate; two acidic residues (Glu, Asp) |
| Appearance | White to off-white powder |
| Solubility | Soluble in H2O (~100 mg/mL); soluble in DMSO (~250 mg/mL) |
| Purity | >=98.0% (HPLC); >=99.0% available on request |
| Identity | Confirmed by LC-MS |
| Grade | Research grade |
| Counter-ion | Lot-specific (acetate or TFA, declared on COA) |
| Moisture | <=10.0% (Karl Fischer) |
| Storage | -20C, desiccated, protected from light |
| Packaging | 1 mg / 5 mg / 10 mg / 50 mg / 100 mg vial; bulk on request |
| Application | Laboratory research use only |
| Origin | China |
Product Details
1. Overview
Epitalon is a short synthetic peptide corresponding to the AEDG sequence, identified as the active component of Epithalamin, a pineal gland extract studied extensively in Russian gerontology research. The tetrapeptide is characterized by two acidic residues (glutamic acid and aspartic acid) and a free C-terminal glycine, giving it a net negative charge at physiological pH. Knowlux supplies Epitalon strictly as a research-grade peptide; it is not approved as a medicinal product in any jurisdiction, and supply is restricted to laboratory investigation channels.
2. Structural Profile
The four-residue backbone comprises alanine, glutamic acid, aspartic acid and glycine. The absence of terminal blocking groups and the presence of two carboxylate side chains distinguish Epitalon from terminally modified peptides in the Semax and Melanotan families. This structural profile contributes to its high aqueous solubility (~100 mg/mL) relative to many research peptides. The short chain length and hydrophilic character influence membrane permeability and stability characteristics in experimental systems.
3. Research Context
Published preclinical descriptions of Epitalon's activities include telomerase activation in cell models, modulation of melatonin secretion in pineal research, and antioxidant effects in oxidative stress paradigms. These observations are derived from in vitro and animal studies and do not establish clinical efficacy or safety. The peptide is also used as a reference standard in HPLC and LC-MS analytical method development for short hydrophilic peptides.
Quality Control
| Test Item | Method | Acceptance Criteria |
|---|---|---|
| Purity | RP-HPLC | >=98.0% |
| Identity & Molecular Mass | LC-MS (deconvoluted) | Consistent with structure |
| Single Impurity | RP-HPLC | <=2.0% |
| Peptide Content | Amino Acid Analysis | >=75.0% |
| Amino Acid Composition | AAA | +/-15% of theoretical |
| Acetate Content | Ion chromatography | 5.0% to 12.0% (where applicable) |
| Water Content | Karl Fischer | <=10.0% |
| Appearance | Visual | White to off-white powder |
Solubility and Handling
Solubility: Epitalon is freely soluble in water, with reported solubility up to approximately 100 mg/mL, and soluble in DMSO at up to 250 mg/mL. Prepare solutions fresh and aliquot to avoid repeated freeze-thaw cycles.
Handling Precautions: Use powder-handling containment (glove box or fume hood with particulate control). Avoid inhalation of fine powder. Wear nitrile gloves, lab coat, and eye protection. Follow institutional chemical hygiene plans for research peptides.
Storage and Stability
| Format | Temperature | Shelf Life |
|---|---|---|
| Lyophilized Powder | -20C, sealed, desiccated | 1 to 3 years (supplier-dependent) |
| Lyophilized Powder | 4C, sealed, desiccated | Short-term (weeks) |
| Reconstituted Solution | -80C, aliquoted | 6 months |
| Reconstituted Solution | -20C, aliquoted | 1 month |
Documentation Support
Per lot: COA, MSDS, HPLC chromatogram, and mass spectrometry data. Custom specifications and third-party inspection available on a project basis.
Compliance Statement
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.
This product is supplied for laboratory research purposes only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Epitalon is not approved as a medicinal product in any jurisdiction. The purchaser is responsible for verifying product specifications against their specific research requirements and for compliance with all applicable institutional, local, and national regulations governing research chemical acquisition, storage, and use. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
