Humanin (human) | CAS 330936-69-1 | Mitochondrial-Derived Neuroprotective Peptide (Research Use Only) | Knowlux

Product Description

Humanin (human), CAS 330936-69-1, is a synthetic 24-amino-acid mitochondrial-derived peptide supplied by Knowlux for laboratory research use. It is also known as HN, Putative humanin peptide, or 1-24-Protein humanin. The peptide sequence is Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala, with a single cysteine residue at position 8. The molecular formula is C119H204N34O32S2 and the molecular weight is 2687.23 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Data conflict and form clarification: A notable discrepancy exists in the published literature regarding the molecular formula for humanin. MedChemExpress, Biorbyt and Bachem datasheets consistently report C119H204N34O32S2 / 2687.23 g/mol. Eurogentec lists a formula of C137H212N42O39S / 2687.4 g/mol, which differs in atom count despite a similar molecular weight; this may reflect a different salt form or a typographical variation. Knowlux reports the formula and weight consistent with the MedChemExpress and Bachem reference standards (C119H204N34O32S2, 2687.23) and declares the counter-ion and assay basis on each COA. Humanin is an investigational research peptide and is not approved as a therapeutic product in any jurisdiction.

Product Parameters

Product Details

1. Overview

Humanin is a 24-amino-acid micropeptide encoded by an open reading frame within the mitochondrial 16S ribosomal RNA gene. It was first identified in the occipital lobe of a patient with familial Alzheimer's disease, and has since been characterized as a mitochondria-derived peptide with broad cytoprotective and neuroprotective activities. Unlike classical secreted hormones, humanin lacks a signal peptide and is thought to act both intracellularly and extracellularly after release from mitochondria. In research settings, humanin is studied as a model mitochondrial-derived peptide (MDP) for investigating apoptosis regulation, amyloid-beta toxicity, and metabolic signalling. Knowlux supplies humanin as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug product.

2. Mechanism of Action (Research Context)

Published research describes humanin as a multi-target cytoprotective peptide with several characterized mechanisms. The most extensively documented is its interaction with pro-apoptotic BCL-2 family proteins: humanin binds to BAX and prevents its translocation from the cytosol to mitochondria, and also binds to BID and BIM, inhibiting their activation of BAX/BAK and the subsequent release of apoptogenic proteins. Humanin also acts as a ligand for the formyl peptide receptors FPR2/FPRL1 and FPR3/FPRL2, and has been reported to inhibit amyloid-beta fibril formation. In the context of Alzheimer's disease research, humanin has been shown to protect neurons from amyloid-beta-induced toxicity and to improve hippocampal acetylcholine levels in preclinical models. Additionally, humanin has been reported to promote mitochondrial biogenesis and improve insulin sensitivity in animal models. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of humanin for Alzheimer's treatment, neuroprotection, anti-aging, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for mitochondrial-derived peptide analytical method development

• In vitro BAX/BID/BIM binding and apoptosis regulation studies

• Amyloid-beta toxicity and Alzheimer's disease research models

• FPR2/FPRL1 receptor signalling research

• Metabolic function and insulin sensitivity research models

• LC-MS and immunoassay calibrators

5. Packaging, Storage & Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C or -80 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Humanin is an endogenous mitochondrial peptide and is not approved as a therapeutic product in any jurisdiction. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.