Vitamin K2 (Menaquinone) | CAS 11032-49-8 | Menaquinone Class (Research Use Only) | Knowlux

Product Description

Vitamin K2, CAS 11032-49-8, is a class designation for a family of menaquinone compounds supplied by Knowlux for laboratory research use. It is not a single molecular entity but a group of 2-methyl-1,4-naphthoquinone derivatives distinguished by the number of isoprene units in the side chain at the 3-position, denoted as MK-n. The generalized empirical formula is (C5H8)n.C11H8O2, reflecting the variable isoprenoid chain length. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Mixture and specification clarification: Because CAS 11032-49-8 describes the menaquinone class rather than a specific homologue, the molecular formula and weight depend on which MK-n is present. Common commercial forms include MK-4 (C31H40O2, 444.65 g/mol) and MK-7 (C46H64O2, 649.0 g/mol; USP reference standard CAS 2124-57-4). Knowlux declares the specific MK-n homologue, its purity, and the carrier matrix (powder or oil) on each COA. Buyers should confirm which menaquinone homologue their research requires, as MK-4 and MK-7 differ in side-chain length, lipophilicity, and reported half-life. Commercial listings describe Vitamin K2 as a bone-health supplement or food fortifier; those designations attach to compliant food and supplement supply chains and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Vitamin K2 is the collective name for a series of menaquinones, a class of fat-soluble vitamins characterized by a 2-methyl-1,4-naphthoquinone core with an unsaturated isoprenoid side chain at the 3-position. The number of isoprene units defines the homologue: MK-4 has four units (C31H40O2), MK-7 has seven (C46H64O2), and longer-chain forms such as MK-9 also occur naturally. In research settings, menaquinones are studied as cofactors in electron transport, as substrates for vitamin K-dependent carboxylase enzymes, and as model compounds for lipid-soluble vitamin biochemistry. Knowlux supplies Vitamin K2 as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished supplement or drug product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes menaquinones as compounds studied in in vitro and in vivo research models. Their defining biochemical role is as a cofactor for gamma-glutamyl carboxylase, which converts specific glutamate residues in vitamin K-dependent proteins (including osteocalcin and matrix Gla protein) to gamma-carboxyglutamate, enabling calcium binding and protein function. MK-4 is also reported to be synthesized endogenously in mammals from phylloquinone (vitamin K1) via cleavage and prenylation. Research has investigated menaquinone effects on bone metabolism, vascular calcification, and cellular signalling in various model systems. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Vitamin K2 for bone health, cardiovascular protection, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for menaquinone analytical method development (HPLC, LC-MS)

• In vitro gamma-glutamyl carboxylase and vitamin K-dependent protein research

• Bone metabolism and vascular calcification research models

• Comparative studies of MK-4 vs. MK-7 biochemistry and bioavailability

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Vitamin K2 is sensitive to light and should be protected from direct exposure. Primary containment: amber glass vial or high-barrier aluminium pouch under nitrogen headspace, sealed with tamper-evident closure. Secondary packaging: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, homologue declaration report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Vitamin K2 (as menaquinone-7) is authorised as a novel food in the European Union for food supplements at specified levels, and menaquinone-4 is used as a food additive and pharmaceutical active in some jurisdictions. Those regulatory positions attach to compliant food- and supplement-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.