alpha-Lipoic Acid | CAS 1077-28-7 | Mitochondrial Cofactor Antioxidant (Research Use Only) | Knowlux

Product Description

alpha-Lipoic Acid, CAS 1077-28-7, is a synthetic organosulfur compound supplied by Knowlux for laboratory research use. It is also known as thioctic acid, DL-alpha-lipoic acid, or ALA. The molecule is a cyclic disulfide-containing pentanoic acid derivative, and the CAS number 1077-28-7 refers to the racemic (DL) form, which is the standard commercial grade. The molecular formula is C8H14O2S2 and the molecular weight is 206.33 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Enantiomer and form clarification: alpha-Lipoic acid exists as two enantiomers: the naturally occurring R-(+)-form (CAS 1200-22-2) and the synthetic racemic DL-form (CAS 1077-28-7). The CAS 1077-28-7 describes the racemic mixture, which is the form most widely traded and the form supplied by Knowlux unless otherwise specified. The R-enantiomer is the biologically active form in mitochondrial enzyme complexes, and some research applications may require it specifically. Buyers should confirm whether their work requires the racemic or enantiopure material. Commercial listings describe alpha-lipoic acid as an antioxidant supplement or a treatment for diabetic neuropathy; those designations attach to supplement or approved pharmaceutical markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

alpha-Lipoic acid is an organosulfur compound that functions as a cofactor for mitochondrial enzyme complexes, including pyruvate dehydrogenase and glycine decarboxylase. It is unique among antioxidants in that it is soluble in both aqueous and lipid phases, and it can regenerate other antioxidants such as glutathione and vitamin C after they have been oxidised. The molecule is synthesised chemically for commercial supply; the racemic DL-form (CAS 1077-28-7) is the standard grade, while the R-enantiomer is produced by resolution or asymmetric synthesis. Knowlux supplies the racemic form as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished supplement or drug product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes alpha-lipoic acid as a mitochondrial cofactor and antioxidant studied in in vitro and in vivo research models. Its reduced form, dihydrolipoic acid, directly scavenges reactive oxygen species, recycles oxidised glutathione and vitamin C, and modulates transcription factor activity, particularly NF-kappaB. In a mouse model of high-fat diet-induced nonalcoholic fatty liver disease, oral alpha-lipoic acid (100 or 200 mg/kg) was reported to reduce visceral fat mass, inhibit appetite, and cause weight loss. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of alpha-lipoic acid for diabetic neuropathy treatment, weight loss, antioxidant supplementation, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for organosulfur compound analytical method development

• In vitro antioxidant capacity and radical scavenging assays

• Mitochondrial enzyme cofactor and metabolic pathway research models

• Glutathione recycling and redox biology studies

• Nonalcoholic fatty liver disease and metabolic syndrome research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

alpha-Lipoic acid is sensitive to light and moisture. Primary containment: amber glass vial or high-barrier aluminium pouch under nitrogen headspace, sealed with tamper-evident closure. Secondary packaging: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. alpha-Lipoic acid is available as a food supplement in some jurisdictions and is used as an active ingredient in medicinal products for diabetic neuropathy in others. The European Medicines Agency has noted a risk of insulin autoimmune syndrome (IAS) associated with thioctic acid treatment, particularly in patients carrying certain HLA genotypes. Those regulatory positions and safety considerations attach to the approved pharmaceutical and supplement products and do not extend to this research-grade supply as sold by Knowlux. alpha-Lipoic acid carries a GHS classification of H302, H315, H317, H319 and H411; appropriate handling and disposal precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.