(-)-Epigallocatechin Gallate (EGCG) | CAS 989-51-5 | Green Tea Catechin (Research Use Only) | Knowlux

Product Description

(-)-Epigallocatechin Gallate (EGCG), CAS 989-51-5, is a naturally occurring catechin polyphenol supplied by Knowlux for laboratory research use. It is the most abundant catechin in green tea and is an ester of epigallocatechin and gallic acid. The molecular formula is C22H18O11 and the molecular weight is 458.37 g/mol (anhydrous basis). Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Hydrate and form clarification: CAS 989-51-5 is consistently recorded across PubChem, Sigma-Aldrich and TCI as (-)-epigallocatechin gallate. Commercial material is frequently supplied as a hydrate (C22H18O11.xH2O), and TCI lists the anhydrous molecular weight as 458.38 with a water content specification of max 5.0%. Knowlux declares the hydrate form and water content on each COA. EGCG is light-sensitive, air-sensitive, and readily oxidises in solution; amber packaging under inert gas is a functional requirement, not a presentation choice. Commercial listings describe EGCG as an antioxidant supplement or cosmetic ingredient; those designations attach to food and cosmetic markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

(-)-Epigallocatechin gallate is the principal catechin in green tea, accounting for a substantial fraction of the total catechins in fresh tea leaves. Structurally, it is a flavan-3-ol esterified with gallic acid at the 3-position, a feature that distinguishes it from simpler catechins such as epicatechin. The molecule is highly susceptible to oxidative degradation and epimerisation, particularly in aqueous solution at elevated temperature or pH. In research settings, EGCG is studied as a model polyphenol for antioxidant mechanisms, protein interactions, and cellular signalling pathways. Knowlux supplies EGCG as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished supplement or drug product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes EGCG as a polyphenol studied in in vitro and in vivo research models. Its vicinal trihydroxyl groups on the galloyl moiety contribute to strong radical-scavenging activity, and it has been reported to interact with a range of cellular targets including the EGFR/HER2/HER3 signalling axis and apoptotic regulators such as Bcl-2/Bax and caspases. In a mouse model of beta-amyloid-induced neurotoxicity, EGCG was reported to reduce neuronal apoptosis through reactive oxygen species scavenging. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of EGCG for anti-aging, cancer prevention, neuroprotection, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in EGCG supply are related to oxidative degradation (EGCG is light-sensitive and air-sensitive, and oxidises readily in solution), epimerisation, and moisture content. A nominal HPLC purity can conceal oxidised or epimerised species; buyers should require a specific chromatographic assay with a declared limit for related catechins and oxidation products, a water content specification, and a specific rotation value, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for catechin and polyphenol analytical method development

• In vitro antioxidant capacity and radical scavenging assays

• Protein-polyphenol interaction and aggregation studies

• Cellular signalling pathway research (EGFR, apoptotic regulators)

• Stability and degradation pathway studies for catechins

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

EGCG is light-sensitive and air-sensitive. Primary containment: amber glass vial or high-barrier aluminium pouch under nitrogen headspace, sealed with tamper-evident closure. Secondary packaging: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, water content report, specific rotation report, catechin profile report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. EGCG is authorised as a novel food ingredient in the European Union in the form of a highly purified extract from green tea leaves, subject to specific conditions of use. In China, EGCG is listed as a used cosmetic ingredient with a maximum historical use level of 0.0098% in oral care products. Those regulatory positions attach to compliant food- and cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. EGCG carries a GHS classification of H302 (harmful if swallowed), H317 (may cause an allergic skin reaction), H319 (serious eye irritation) and H411 (aquatic toxicity); appropriate handling and disposal precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.