Fisetin | CAS 528-48-3 | Flavonoid Polyphenol (Research Use Only) | Knowlux

Product Description

Fisetin, CAS 528-48-3, is a naturally occurring flavonoid polyphenol supplied by Knowlux for laboratory research use. It is a tetrahydroxyflavone, also known as 3,3',4',7-tetrahydroxyflavone or 5-desoxyquercetin, distinguished from quercetin by the absence of a hydroxyl group at the 5-position. The molecular formula is C15H10O6 and the molecular weight is 286.24 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Source and identity clarification: Fisetin occurs naturally in strawberries, apples, persimmons, onions, and certain woods such as Rhus succedanea and Cotinus coggygria. Commercial material may be obtained by botanical extraction or by multi-step chemical synthesis; the sourcing route affects impurity profiles and traceability documentation. Knowlux declares the source and assay basis on each COA. Commercial listings describe fisetin as an anti-aging or senolytic supplement ingredient; those designations attach to unregulated supplement markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Fisetin is a flavonol belonging to the flavonoid class of polyphenols. It was first isolated in the 19th century from sumac and young fustic wood and has since been identified in a range of fruits and vegetables. Structurally, it is a tetrahydroxyflavone with hydroxyl groups at positions 3, 7, 3' and 4', a pattern that underlies its antioxidant and metal-chelating properties. In research settings, fisetin has been studied primarily as a senolytic agent, a neuroprotective antioxidant, and a modulator of PI3K/Akt/mTOR signalling. Knowlux supplies fisetin as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished supplement or drug product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes fisetin as a flavonoid studied in in vitro and in vivo research models. It has been reported to inhibit PI3K, Akt, mTOR and Cdk6, and to exhibit neuroprotective and antioxidant activities in mouse models of neurodegeneration. In a mouse traumatic brain injury model, fisetin improved neurological function and reduced cerebral edema and lesion volume, with effects attributed partly to activation of the Nrf2-ARE pathway. Additional research has investigated its senolytic activity, anti-inflammatory effects, and influence on lipid accumulation in adipocyte models. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of fisetin for anti-aging, senolytic therapy, cognitive enhancement, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in fisetin supply are related to co-eluting related flavonoids (quercetin and kaempferol are common botanical companions), residual solvents from extraction or synthesis, and moisture uptake. A nominal HPLC purity can conceal related flavonoid content; buyers should require a specific chromatographic assay with a declared limit for quercetin and related substances, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for flavonoid analytical method development

• In vitro antioxidant capacity and Nrf2-ARE pathway research models

• Senolytic activity and cellular senescence research models

• PI3K/Akt/mTOR signalling pathway studies

• Neuroprotection and traumatic brain injury research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Fisetin is sensitive to light and moisture. Primary containment: amber glass vial or high-barrier aluminium pouch under nitrogen headspace, sealed with tamper-evident closure. Secondary packaging: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, related flavonoid report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Fisetin has no approved therapeutic indication; marketing it as a disease-treatment ingredient or finished drug is not justified by RUO supply. Any food, dietary, cosmetic, or investigational drug pathway requires its own status review, safety and manufacturing basis, labeling controls, and, for pharmaceutical development, appropriately phased cGMP and regulatory submissions. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.