Pterostilbene | CAS 537-42-8 | Stilbenoid Polyphenol (Research Use Only) | Knowlux

Product Description

Pterostilbene, CAS 537-42-8, is a naturally occurring or synthetic stilbenoid polyphenol supplied by Knowlux for laboratory research use. It is a dimethylated analogue of resveratrol, characterized by two methoxy groups on the A-ring and a single hydroxyl on the B-ring. The molecular formula is C16H16O3 and the molecular weight is 256.30 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Isomeric and source clarification: CAS 537-42-8 describes the pterostilbene molecule, but the trans-isomer is the biologically relevant and commercially supplied form. Knowlux declares the trans-content on each COA. Pterostilbene can be sourced from natural extraction (e.g., Pterocarpus heartwood, blueberries) or chemical synthesis; the sourcing route affects impurity profiles and traceability documentation. Buyers should confirm whether their research requires a specific origin. Commercial listings describe pterostilbene as an antioxidant supplement or anti-aging ingredient; those designations attach to supplement markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Pterostilbene is a stilbenoid polyphenol structurally related to resveratrol but distinguished by two methoxy substitutions that increase its lipophilicity and metabolic stability. It is found naturally in small quantities in certain berries and in the heartwood of Pterocarpus species. In research settings, pterostilbene is studied as a lipophilic antioxidant and as a tool compound for investigating stilbenoid pharmacology in cellular and animal models. Knowlux supplies pterostilbene as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished supplement or drug product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes pterostilbene as a stilbenoid studied in in vitro and in vivo research models. Its methoxy groups enhance cellular uptake and reduce phase II metabolism relative to resveratrol, properties that have made it a subject of interest in bioavailability and metabolic studies. Research has investigated its effects on oxidative stress markers, inflammatory pathways, and cellular signalling in various model systems. A patent filing describes anxiolytic-like effects of pterostilbene in a mouse model, with activity observed at 1-2 mg/kg doses and detection in brain tissue after oral administration. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of pterostilbene for anti-aging, antioxidant supplementation, cognitive enhancement, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in pterostilbene supply are related to cis-isomer content (which can be concealed by nominal HPLC purity and is pharmacologically distinct) and photodegradation. Buyers should require a stated trans-content limit, a stability-indicating method, and amber packaging with oxygen exclusion, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for stilbenoid analytical method development

• In vitro antioxidant capacity and cellular uptake studies

• Stilbenoid metabolism and bioavailability research models

• Comparative studies of resveratrol analogues

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Pterostilbene is sensitive to light, air, and heat. Primary containment: amber glass vial or high-barrier aluminium pouch under nitrogen headspace, sealed with tamper-evident closure. Secondary packaging: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, trans-isomer content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Pterostilbene is sold as a dietary supplement ingredient in some jurisdictions; those regulatory positions attach to compliant supplement-supply chains and do not apply to, and are not represented by, this research-grade lot. Pterostilbene carries a GHS classification of H318 (serious eye damage) and H411 (aquatic toxicity); appropriate handling and disposal precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.