Tetracycline Hydrochloride | CAS 64-75-5 | Tetracycline Antibiotic (Research Use Only) | Knowlux

Product Description

Tetracycline Hydrochloride, CAS 64-75-5, is a broad-spectrum tetracycline antibiotic supplied by Knowlux for laboratory research use. It is the hydrochloride salt of tetracycline, a polyketide-derived antibiotic produced by Streptomyces species. The molecular formula is C22H24N2O8.HCl and the molecular weight is 480.9 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: CAS 64-75-5 is consistently recorded across ChemicalBook, pharmacopoeial standards and API manufacturer listings as the hydrochloride salt of tetracycline. The free base form is a distinct entity. Knowlux supplies the hydrochloride salt explicitly and declares the counter-ion on each COA. Commercial listings describe tetracycline hydrochloride as a veterinary API, feed additive, or pet reagent; those designations attach to approved veterinary or industrial products and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Tetracycline hydrochloride is the salt form of tetracycline, a first-generation tetracycline antibiotic isolated from Streptomyces species in the 1940s. It is active against a broad range of Gram-positive and Gram-negative bacteria, as well as certain atypical organisms including chlamydiae, mycoplasmas, and rickettsiae. The hydrochloride salt improves aqueous solubility relative to the free base and is the form used in many pharmaceutical and veterinary applications. Knowlux supplies tetracycline hydrochloride as a research-grade material for laboratory and analytical use; this supply is not intended for human or veterinary administration and does not constitute a finished drug product.

2. Mechanism of Action (Research Context)

Published research describes tetracycline as an inhibitor of bacterial protein synthesis. It binds to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and preventing the addition of new amino acids to the growing polypeptide chain. This mechanism is bacteriostatic, relying on the host immune system to clear the infection. Resistance to tetracyclines commonly occurs through efflux pumps or ribosomal protection proteins. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of tetracycline hydrochloride for antibiotic treatment or any clinical indication is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for tetracycline antibiotic analytical method development

• In vitro 30S ribosomal subunit binding and protein synthesis inhibition studies

• Bacterial susceptibility testing and resistance mechanism research models

• Epimerisation and degradation pathway studies

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, counter-ion specification, epimer impurity report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or veterinary administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Tetracycline hydrochloride is approved as a prescription antibiotic and as a veterinary product in many jurisdictions; that regulatory status is specific to the approved pharmaceutical and veterinary products and does not extend to this research-grade supply as sold by Knowlux. Tetracycline hydrochloride is listed under HS code 2941.30.00 for tetracyclines and their salts, with a Q regulatory condition (import drug clearance) in China. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.