Lincomycin Hydrochloride | CAS 859-18-7 | Lincosamide Antibiotic (Research Use Only) | Knowlux

Product Description

Lincomycin Hydrochloride, CAS 859-18-7, is a lincosamide antibiotic supplied by Knowlux for laboratory research use. It is produced by fermentation of Streptomyces lincolnensis var. lincolnensis and is formulated as the hydrochloride salt to improve aqueous solubility. The molecular formula is C18H34N2O6S.HCl and the molecular weight is 443.00 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: CAS 859-18-7 is consistently recorded across Sigma-Aldrich, GuideChem and ChemicalBook as the hydrochloride salt of lincomycin. The free base form is a distinct entity. Some supplier listings report the molecular formula as C18H35ClN2O6S (a combined notation equivalent to the salt), while GuideChem reports C18H34N2O6S.HCl (dot-separated). Both describe the same salt with molecular weight 443.00. Knowlux reports the dot-separated formula consistent with the GuideChem reference and declares the counter-ion on each COA. A monohydrate form (C18H34N2O6S.HCl.H2O, 461.02 g/mol) is a distinct hydrate and should not be conflated with the anhydrous salt. Commercial listings describe lincomycin hydrochloride as a veterinary API or feed additive; those designations attach to approved veterinary products and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Lincomycin is a lincosamide antibiotic first isolated from Streptomyces lincolnensis in the 1960s. It is active primarily against Gram-positive bacteria and certain anaerobic bacteria, and has been used clinically and in veterinary medicine for infections caused by susceptible organisms. The hydrochloride salt form is the commercially relevant solid form, offering high aqueous solubility (50 mg/mL) and stability suitable for laboratory handling. Knowlux supplies lincomycin hydrochloride as a research-grade material for laboratory and analytical use; this supply is not intended for human or veterinary administration and does not constitute a finished drug product.

2. Mechanism of Action (Research Context)

Published research describes lincomycin as an inhibitor of bacterial protein synthesis. It binds to the 23S rRNA peptidyl transferase region of the 50S ribosomal subunit, forming a cross-link that interferes with peptide bond formation and blocks elongation of the nascent polypeptide chain. This mechanism is shared with other lincosamides such as clindamycin. The antibiotic spectrum is primarily Gram-positive, with activity against staphylococci, streptococci, and certain anaerobes, though resistance can occur through ribosomal methylation or enzymatic inactivation. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of lincomycin hydrochloride for antibiotic treatment or any clinical indication is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in lincomycin hydrochloride supply are related to residual fermentation by-products (including lincomycin B, which has lower activity and higher toxicity) and moisture uptake. Buyers should require a specific chromatographic assay with a declared limit for lincomycin B and related substances, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for lincosamide antibiotic analytical method development

• In vitro bacterial protein synthesis inhibition studies

• 23S rRNA binding and ribosomal interaction research

• Antimicrobial susceptibility testing and resistance mechanism research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, counter-ion specification, lincomycin B report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or veterinary administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Lincomycin hydrochloride is approved as a prescription antibiotic and as a veterinary product in many jurisdictions; that regulatory status is specific to the approved pharmaceutical and veterinary products and does not extend to this research-grade supply as sold by Knowlux. Lincomycin hydrochloride carries a GHS classification of H315 (skin irritation), H319 (serious eye irritation) and H335 (respiratory irritation); appropriate handling precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.