Miconazole Nitrate | CAS 22832-87-7 | Imidazole Antifungal (Research Use Only) | Knowlux

Product Description

Miconazole Nitrate, CAS 22832-87-7, is a synthetic imidazole antifungal agent supplied by Knowlux for laboratory research use. It is also known as R18134 nitrate or miconazole nitrate. The molecular formula is C18H14Cl4N2O.HNO3 and the molecular weight is 479.14 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: CAS 22832-87-7 is consistently recorded across the FDA, Sigma-Aldrich and PubChem as the nitrate salt of miconazole. The free base form (miconazole) is a distinct entity with a different CAS. Knowlux supplies the nitrate salt explicitly and declares the counter-ion on each COA. Commercial listings describe miconazole nitrate as an antifungal API or a veterinary product; those designations attach to approved pharmaceutical or veterinary products and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Miconazole nitrate is a broad-spectrum imidazole antifungal agent that is active against dermatophytes, yeasts, and other fungi. It is approved by the FDA in topical and vaginal formulations for the treatment of fungal infections such as vulvovaginal candidiasis, and is also used in veterinary medicine for fungal skin infections in dogs and cats. The compound is poorly absorbed from the gastrointestinal tract and is typically applied topically. Knowlux supplies miconazole nitrate as a research-grade material for laboratory and analytical use; this supply is not intended for human or veterinary administration and does not constitute a finished drug product.

2. Mechanism of Action (Research Context)

Published research describes miconazole as an imidazole antifungal that inhibits cytochrome P450-dependent 14-alpha-demethylase, an enzyme required for the conversion of lanosterol to ergosterol in fungal cell membranes. Inhibition of ergosterol synthesis increases membrane permeability, causing leakage of cellular contents and ultimately fungal cell death. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, and interfere with triglyceride and phospholipid biosynthesis. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of miconazole nitrate for antifungal treatment or any clinical indication is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for imidazole antifungal analytical method development

• In vitro ergosterol biosynthesis inhibition studies

• Cytochrome P450 14-alpha-demethylase interaction research

• Antifungal susceptibility testing and mechanism research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, counter-ion specification. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Miconazole nitrate is approved as a prescription medicine (topical and vaginal formulations) and as a veterinary product in many jurisdictions; that regulatory status is specific to the approved pharmaceutical and veterinary products and does not extend to this research-grade supply as sold by Knowlux. Miconazole nitrate carries a GHS classification of H302 (harmful if swallowed) and H317 (may cause an allergic skin reaction); appropriate handling precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.