Flubendazole | CAS 31430-15-6 | Benzimidazole Anthelmintic (Research Use Only) | Knowlux

Product Description

Flubendazole, CAS 31430-15-6, is a synthetic benzimidazole anthelmintic supplied by Knowlux for laboratory research use. It is also known as fluoromebendazole or methyl 5-(4-fluorobenzoyl)-2-benzimidazolecarbamate. The molecular formula is C16H12FN3O3 and the molecular weight is 313.28 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Regulatory and form clarification: Flubendazole is not approved by the FDA for any human indication in the United States. The FDA granted Orphan Drug Designation for ascariasis (roundworm) in October 2024, but this designation does not constitute marketing approval. A DailyMed entry for a flubendazole tablet explicitly states that the drug has not been found by FDA to be safe and effective, and the labeling has not been approved by FDA. In veterinary medicine, flubendazole is used in some jurisdictions for gastrointestinal parasite control in pigs and poultry. Commercial listings describe flubendazole as a deworming agent or antiparasitic API; those designations attach to approved veterinary products or investigational human research and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Flubendazole is a fluorinated analogue of mebendazole and a member of the benzimidazole class of anthelmintics. It is very poorly absorbed from the gastrointestinal tract, a property that limits systemic exposure and underlies its use as a locally acting intestinal anthelmintic. The compound has been investigated in human research for neurocysticercosis and as a macrofilaricide, but development by Johnson & Johnson for filariasis was discontinued due to preclinical toxicology findings related to embryonic development in rats. Knowlux supplies flubendazole as a research-grade material for laboratory and analytical use; this supply is not intended for human or veterinary administration and does not constitute a finished drug product.

2. Mechanism of Action (Research Context)

Published research describes flubendazole as a benzimidazole that binds to parasite beta-tubulin and inhibits microtubule polymerisation. In intestinal nematodes, this blocks microtubule-dependent glucose uptake in the absorptive cells of the parasite gut, leading to depletion of glycogen stores and reduced ATP formation, which impairs parasite reproduction and survival. In cestodes, the effect extends to the tegumental cells, causing degenerative changes and parasite death. The selectivity for parasite tubulin over mammalian tubulin is the basis for the therapeutic margin observed in approved veterinary applications. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of flubendazole for deworming, antiparasitic treatment, or any clinical indication is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in flubendazole supply are related to residual starting materials from the synthesis (4-fluorobenzoyl and benzimidazole precursors) and polymorphic form. Buyers should require a specific chromatographic assay and a declared limit for related substances, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for flubendazole analytical method development

• In vitro tubulin binding and microtubule polymerisation studies

• Anthelmintic mechanism research models

• Veterinary parasitology research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Flubendazole is not FDA-approved for any human indication; the FDA Orphan Drug Designation for ascariasis (October 2024) does not constitute marketing approval. Flubendazole carries a GHS classification of H361 (suspected of damaging fertility or the unborn child); appropriate handling precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.