SLU-PP-332 | CAS 303760-60-3 | Pan-ERR Agonist (Research Use Only) | Knowlux

Product Description

SLU-PP-332, CAS 303760-60-3, is a synthetic small-molecule pan-estrogen-related receptor (ERR) agonist supplied by Knowlux for laboratory research use. Its chemical name is (E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide, and it is a phenol amide derivative featuring a salicyloyl hydrazone scaffold linked to a naphthalene ring. The molecular formula is C18H14N2O2 and the molecular weight is 290.32 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: CAS 303760-60-3 is consistently recorded across PubChem, MedChemExpress and GuideChem as SLU-PP-332, with the systematic name 4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide. The compound is typically supplied as a white to off-white solid and is noted to be soluble in DMSO (up to 100 mg/mL with ultrasonic) but practically insoluble in water. Commercial listings describe SLU-PP-332 as a fat-burning or exercise mimetic raw material; those designations attach to unregulated supplement markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

SLU-PP-332 is a pan-agonist of the estrogen-related receptors (ERRalpha, ERRbeta, and ERRgamma), a class of nuclear receptors that regulate mitochondrial biogenesis and oxidative metabolism. It has been investigated in preclinical research models of metabolic disease, muscle function and exercise physiology. The compound was identified through structure-activity optimization of simple phenol amides as ERRgamma agonists, and has served as a chemical probe for dissecting ERR-mediated metabolic pathways. Knowlux supplies SLU-PP-332 as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug or supplement product.

2. Mechanism of Action (Research Context)

Published research describes SLU-PP-332 as a pan-ERR agonist with EC50 values of 98 nM (ERRalpha), 230 nM (ERRbeta) and 430 nM (ERRgamma), indicating preferential activity at ERRalpha. In C2C12 skeletal muscle cells, SLU-PP-332 (0-5 microM, 24 h) increased expression of the ERR target gene Pdk4 and induced mitochondrial biogenesis. In diet-induced obese mouse models, SLU-PP-332 (50 mg/kg, i.p., twice daily for 28 days) induced fatty acid metabolism, reduced fat mass and improved glucose metabolism without altering food intake or brown adipose tissue mass. These descriptions are derived from published preclinical research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of SLU-PP-332 for fat loss, exercise performance enhancement, weight management, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for SLU-PP-332 analytical method development

• In vitro ERRalpha, ERRbeta and ERRgamma binding and functional assay development

• Mitochondrial biogenesis and oxidative metabolism research models

• Skeletal muscle cell function and exercise physiology research

• Metabolic disease model research, including obesity and glucose homeostasis studies

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. SLU-PP-332 is an investigational compound and is not approved as a therapeutic product in any jurisdiction; no human clinical data are available. Commercial listings describing it as a supplement or exercise mimetic are inconsistent with its research-grade status. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.