Galantamine Hydrobromide | CAS 1953-04-4 | Acetylcholinesterase Inhibitor (Research Use Only) | Knowlux

Product Description

Galantamine Hydrobromide, CAS 1953-04-4, is a synthetic alkaloid salt supplied by Knowlux for laboratory research use. It is the hydrobromide salt of galantamine, a benzazepine alkaloid originally isolated from Amaryllidaceae plants such as snowdrop and daffodil species. The molecular formula is C17H22BrNO3 and the molecular weight is 368.27 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: CAS 1953-04-4 is consistently recorded across the FDA Orange Book, ChemicalBook and Santa Cruz Biotechnology as the hydrobromide salt of galantamine. The free base form is a distinct entity with a different CAS. Knowlux supplies the hydrobromide salt explicitly and declares the counter-ion on each COA. Commercial listings describe galantamine hydrobromide as an Alzheimer's medication or a nootropic; those designations attach to approved pharmaceutical products or unregulated supplement markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Galantamine hydrobromide is the salt form of galantamine, a tertiary alkaloid with a unique benzazepine skeleton. It is approved by the FDA as a prescription medicine (Razadyne) for the treatment of mild to moderate Alzheimer's disease. The compound is also used as a research tool for studying cholinergic neurotransmission and nicotinic receptor pharmacology. Knowlux supplies galantamine hydrobromide as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug product.

2. Mechanism of Action (Research Context)

Published research describes galantamine as a competitive and reversible inhibitor of acetylcholinesterase (AChE), with an IC50 of approximately 410 nM. Unlike pure AChE inhibitors, galantamine also acts as an allosteric potentiating ligand at neuronal nicotinic acetylcholine receptors (nAChRs), enhancing the response to acetylcholine without directly activating the receptor. This dual mechanism is thought to increase cholinergic neurotransmission in the brain, which is the basis for its use in Alzheimer's disease research. Additionally, galantamine has been reported to influence the release of other neurotransmitters, including monoamines, glutamate and GABA. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of galantamine hydrobromide for memory enhancement, cognitive improvement, or any therapeutic indication is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for galantamine analytical method development

• In vitro acetylcholinesterase inhibition assays

• Nicotinic acetylcholine receptor allosteric modulation studies

• Cholinergic neurotransmission and Alzheimer's disease model research

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, counter-ion specification. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Galantamine hydrobromide is approved as a prescription medicine (Razadyne) in many jurisdictions for Alzheimer's disease; that regulatory status is specific to the approved pharmaceutical product and does not extend to this research-grade supply as sold by Knowlux. Galantamine hydrobromide carries a GHS classification of H301 (toxic if swallowed); appropriate handling precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.