Phenibut | CAS 1078-21-3 | GABA-B Receptor Agonist (Research Use Only) | Knowlux

Product Description

Phenibut, CAS 1078-21-3, is a synthetic GABA analogue supplied by Knowlux for laboratory research use. It is also known as beta-phenyl-gamma-aminobutyric acid, Fenibut, or Noophen, and its chemical name is 4-amino-3-phenylbutanoic acid. The molecular formula is C10H13NO2 and the molecular weight is 179.22 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Regulatory and safety clarification: Phenibut is not approved by the FDA for any indication in the United States and is not a lawful dietary-supplement ingredient; the FDA has explicitly identified phenibut as an unlawful ingredient in dietary supplements and has recommended recalls of products containing it. It was developed in the Soviet Union and has been used clinically in Russia and some Eastern European countries as an anxiolytic and nootropic, but it lacks FDA or EMA marketing authorisation. Phenibut carries dependence and withdrawal risks; published case reports document addiction and severe withdrawal syndromes. Commercial listings describe it as a nootropic or anxiolytic powder; those designations attach to unregulated supplement markets and do not apply to, and are not represented by, this research-grade lot. Knowlux supplies the free base form explicitly; the hydrochloride salt is a distinct entity and should not be conflated with this product.

Product Parameters

Product Details

1. Overview

Phenibut is a synthetic derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), modified by the addition of a phenyl ring that confers lipophilicity and facilitates passage across the blood-brain barrier. It was developed in the Soviet Union in the 1960s and has been used clinically in Russia and some Eastern European countries as an anxiolytic, tranquilliser and nootropic agent. It is not a racetam and is structurally distinct from the piracetam family. Knowlux supplies Phenibut as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug or supplement product.

2. Mechanism of Action (Research Context)

Published research describes Phenibut as a GABA-B receptor agonist, acting as a GABA-mimetic primarily at GABA-B sites. It has also been reported to stimulate dopamine receptors and to antagonise beta-phenethylamine (PEA), a putative endogenous anxiogenic compound. These mechanisms are derived from published preclinical and clinical literature on Phenibut as a pharmaceutical agent in jurisdictions where it is approved; they are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Phenibut for anxiety relief, sleep improvement, nootropic use, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply. Phenibut carries documented risks of dependence, tolerance and severe withdrawal; these risks are noted for safety awareness and do not constitute medical advice.

3. Quality Control

4. Applications

• Reference standard for Phenibut analytical method development

• In vitro GABA-B receptor binding and functional assay development

• Comparative studies of GABA analogues and phenyl-substituted neurotransmitters

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Phenibut is not FDA-approved for any indication in the United States and is not a lawful dietary-supplement ingredient; the FDA has identified phenibut as an unlawful ingredient in dietary supplements and has recommended recalls of products containing it. Phenibut carries dependence and withdrawal risks; published case reports document addiction and severe withdrawal syndromes. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.