Sunifiram (DM-235) | CAS 314728-85-3 | AMPA Receptor Modulator (Research Use Only) | Knowlux

Product Description

Sunifiram, CAS 314728-85-3, is a synthetic piperazine-derived compound supplied by Knowlux for laboratory research use. It is also known as DM-235 or DM235. The molecular formula is C14H18N2O2 and the molecular weight is 246.30 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Regulatory and safety clarification: Sunifiram is not approved by the FDA for any indication, and no human clinical trials have been conducted. It is not a permitted dietary-supplement ingredient. BenchChem documentation explicitly states that Sunifiram has not undergone extensive toxicology testing and is not approved for human use. The compound is structurally related to piracetam but is chemically classified as a piperazine alkaloid rather than a racetam. Commercial listings describe it as a nootropic or brain enhancer; those designations attach to unregulated supplement markets and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Sunifiram is a piperazine-derived research compound that has been investigated for its effects on learning and memory in preclinical models. Despite structural similarities to piracetam, Sunifiram is chemically distinct: it contains a 1,4-diaminocyclohexane core with N-benzoyl and N-propanoyl substituents, and is classified as a piperazine alkaloid rather than a racetam. It was first described by the Gualtieri research group, and preclinical studies report that it is approximately 10,000-fold more potent than piracetam in certain cognitive models. Knowlux supplies Sunifiram as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug or supplement product.

2. Mechanism of Action (Research Context)

Published preclinical research describes Sunifiram as an ampakine-like compound that modulates AMPA receptor activity. In the mouse passive avoidance test, Sunifiram (0.1 mg/kg i.p.) reversed amnesia induced by the AMPA receptor antagonist NBQX, and this effect was linked to activation of AMPA-mediated neurotransmission. The compound is also reported to influence NMDA receptor activity, potentially through modulation of the glycine binding site. Additional studies suggest a cholinergic component, with Sunifiram increasing acetylcholine release in the rat cerebral cortex. It is important to note that these mechanisms are derived from preclinical animal studies only; no human clinical trials have been conducted, and the precise mechanism of action is not entirely understood. These descriptions are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Sunifiram for memory enhancement, cognitive improvement, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in Sunifiram supply are related to residual starting materials from the synthesis (piperazine and acylating agents) and moisture uptake. Buyers should require a specific chromatographic assay and a declared limit for related substances, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for Sunifiram analytical method development

• In vitro AMPA receptor binding and functional assay development

• Glutamatergic and cholinergic neurotransmission research models

• Comparative studies of ampakine-like compounds

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Sunifiram is not FDA-approved for any indication, and no human clinical trials have been conducted; it has not undergone extensive toxicology testing and is not approved for human use. Sunifiram is not a permitted dietary-supplement ingredient. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.