Oxiracetam | CAS 62613-82-5 | AMPA Receptor Modulator (Research Use Only) | Knowlux

Product Description

Oxiracetam, CAS 62613-82-5, is a synthetic racetam-family compound supplied by Knowlux for laboratory research use. It is also known as 4-hydroxy-2-oxo-1-pyrrolidineacetamide or ISF 2522. The molecular formula is C6H10N2O3 and the molecular weight is 158.16 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Regulatory status clarification: Oxiracetam is not approved by the FDA for any indication in the United States, and is not an accepted dietary-supplement ingredient. The FDA has identified imported oxiracetam products as unapproved new drugs in enforcement actions against nootropic sellers. It has been used as a medicine in some countries for cognitive impairment following brain injury, stroke or dementia, but its clinical evidence is mixed: a 2025 Phase 3 trial in China reported cognitive benefit after brain injury, while a 2026 Korean trial found no benefit for post-stroke cognitive decline, and South Korea has suspended its use. Knowlux supplies oxiracetam as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug or supplement product.

Product Parameters

Product Details

1. Overview

Oxiracetam is a cyclic derivative of gamma-aminobutyric acid (GABA) and a member of the racetam family, structurally related to piracetam and aniracetam. It is water-soluble and has been studied primarily for its effects on cognitive parameters in preclinical and clinical research settings. Unlike aniracetam, oxiracetam is not lipid-soluble, a property that influences its distribution in research models. Knowlux supplies oxiracetam as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug or supplement product.

2. Mechanism of Action (Research Context)

Published research describes oxiracetam as a positive modulator of the AMPA receptor, a glutamate-gated ion channel involved in fast excitatory synaptic transmission. A 2026 study in an Alzheimer's disease mouse model reported that oxiracetam slowed the desensitization rate of AMPAR GluA1 and GluA2 subunits, enhanced hippocampal neuronal reactivity, and improved cognitive function. It has also been reported to enhance protein kinase C (PKC) activity and promote synaptic plasticity in research models. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of oxiracetam for memory enhancement, cognitive improvement, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for oxiracetam analytical method development

• In vitro AMPA receptor binding and functional assay development

• Glutamatergic neurotransmission and synaptic plasticity research models

• Comparative studies of racetam-family compounds

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Oxiracetam is not FDA-approved for any indication in the United States and is not a permitted dietary-supplement ingredient; the FDA has identified imported oxiracetam products as unapproved new drugs. Oxiracetam carries a GHS classification of H315 (skin irritation) and H319 (serious eye irritation); appropriate handling precautions should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.