Oleoylethanolamide (OEA) | CAS 111-58-0 | Fatty Acid Amide (Research Use Only) | Knowlux

Product Description

Oleoylethanolamide (OEA), CAS 111-58-0, is a synthetic fatty acid amide supplied by Knowlux for laboratory research use. It is also known as N-oleoylethanolamine, N-(2-hydroxyethyl)-9Z-octadecenamide, or OEA, and belongs to the N-acylethanolamine family of endogenous lipid mediators. The molecular formula is C20H39NO2 and the molecular weight is 325.53 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Regulatory status clarification: OEA is a naturally occurring metabolite of oleic acid produced in the small intestine, and has been the subject of a New Dietary Ingredient (NDI) notification in the United States. In the European Union, OEA appears in the Novel Food Status Catalogue as an unauthorised Novel Food requiring pre-market authorisation before it can be placed on the market. Commercial listings frequently describe OEA as a food-grade or supplement-grade ingredient; those designations attach to compliant supply chains and do not apply to, and are not represented by, this research-grade lot.

Product Parameters

Product Details

1. Overview

Oleoylethanolamide is an endogenous fatty acid amide derived from oleic acid and ethanolamine. It is produced in the small intestine in response to dietary fat intake and is structurally related to anandamide, though it lacks the psychoactive properties associated with the endocannabinoid system. OEA is best characterised as a satiety signal in research models, where it has been studied for its interactions with peroxisome proliferator-activated receptor alpha (PPAR-alpha) and its effects on food intake and lipid metabolism. Knowlux supplies OEA as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished food or supplement product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes OEA as a lipid mediator studied in in vitro and in vivo research models, with proposed interactions involving PPAR-alpha and effects on satiety signalling and lipid metabolism. It has also been investigated in research models of airway inflammation and metabolic parameters. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of OEA for weight loss, appetite suppression, anti-aging, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

The specification failures that matter most in OEA supply are related to lipid handling: residual oleic acid from incomplete conversion, and moisture uptake that can affect solid-state stability. Buyers should require a specific chromatographic assay and a declared limit for residual fatty acid, not a generic purity figure. Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.

4. Applications

• Reference standard for OEA analytical method development

• In vitro PPAR-alpha binding and functional assay development

• Satiety signalling and lipid metabolism research models

• Comparative studies of N-acylethanolamine family members (OEA, PEA, anandamide)

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. OEA has a melting range of approximately 56-62 C; prolonged exposure to high container temperatures during transit can cause caking, so thermal protection is specified for warm lanes. Cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, residual fatty acid report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. OEA is listed in the EU Novel Food Status Catalogue as an unauthorised Novel Food requiring pre-market authorisation. An NDI notification has been filed in the United States for OEA as a dietary supplement ingredient; those regulatory positions attach to compliant food- and supplement-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.