NADH, Disodium Salt | CAS 606-68-8 | Reduced Coenzyme (Research Use Only) | Knowlux

Product Description

NADH, Disodium Salt, CAS 606-68-8, is a synthetic reduced pyridine dinucleotide coenzyme supplied by Knowlux for laboratory research use. It is also known as beta-NADH, reduced beta-nicotinamide adenine dinucleotide disodium salt, or Coenzyme I reduced form, and is the reduced counterpart of the NAD+/NADH redox pair. The molecular formula is C21H27N7Na2O14P2 and the molecular weight is 709.40 g/mol (anhydrous basis). Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Form and stability clarification: CAS 606-68-8 is consistently recorded across Sigma-Aldrich, MedChemExpress and GuideChem as the disodium salt of reduced beta-nicotinamide adenine dinucleotide. NADH is susceptible to oxidation to NAD+ under residual moisture, dissolved oxygen, light and elevated pH; a lot that meets specification at release can drift off specification after a warm transit lane. Knowlux recommends an explicit reduced-form ratio (enzymatic assay at 340 nm) and a Karl Fischer water limit on the COA for applications where redox state is critical. Commercial listings frequently describe the material as food grade or supplement grade; those designations attach to compliant food-supply chains and do not apply to this research-grade lot.

Product Parameters

Product Details

1. Overview

NADH, disodium salt is the reduced form of beta-nicotinamide adenine dinucleotide, a pyridine dinucleotide coenzyme found in all living cells. Structurally, it consists of a nicotinamide riboside moiety linked via a pyrophosphate bridge to an adenosine monophosphate moiety, with the nicotinamide ring in the reduced (1,4-dihydro) state. The molecule functions as a soluble electron donor in dehydrogenase-catalysed oxidation-reduction reactions, transferring hydride to the respiratory chain and participating in glycolysis, beta-oxidation and the TCA cycle. Knowlux supplies NADH as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished food or supplement product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes NADH as a central metabolite in cellular energy metabolism and a regenerative electron donor for redox enzymes. It has been studied in research models of mitochondrial function, fatigue and metabolic parameters. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of NADH for energy enhancement, anti-fatigue, cognitive support, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for NAD+/NADH redox pair analytical method development

• In vitro dehydrogenase and oxidoreductase enzyme assays

• Cellular energy metabolism and mitochondrial function studies

• LC-MS and biochemical assay calibrators

• Stability and formulation screening for reduced dinucleotide actives

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement, reduced-form ratio report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. NADH is sold as a dietary supplement ingredient in some jurisdictions and is regulated differently across markets; those regulatory positions attach to compliant food- and supplement-grade supply chains and do not apply to, and are not represented by, this research-grade lot. The reduced form is oxidation-sensitive; appropriate handling and storage controls should be observed. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.