Beta-Nicotinamide Adenine Dinucleotide (NAD+) | CAS 53-84-9 | Redox Coenzyme (Research Use Only) | Knowlux

Product Description

Beta-Nicotinamide Adenine Dinucleotide, CAS 53-84-9, is a synthetic pyridine dinucleotide coenzyme supplied by Knowlux for laboratory research use. It is also known as beta-NAD, NAD+, diphosphopyridine nucleotide, or Coenzyme I, and is the oxidised form of the NAD+/NADH redox pair. The molecular formula is C21H27N7O14P2 and the molecular weight is 663.43 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Form and identity clarification: CAS 53-84-9 is consistently recorded across PubChem, Sigma-Aldrich, MedChemExpress and GuideChem as the oxidised form of beta-nicotinamide adenine dinucleotide. The reduced form (NADH) is a distinct entity with a different CAS. Knowlux supplies the oxidised form explicitly and declares the counter-ion and assay basis on each COA. Commercial listings frequently describe the material as food grade or supplement grade; those designations attach to compliant food-supply chains and do not apply to this research-grade lot. Customs authorities in some jurisdictions have flagged NAD+ for enhanced scrutiny when presented as a food or supplement ingredient.

Product Parameters

Product Details

1. Overview

Beta-Nicotinamide Adenine Dinucleotide (NAD+) is a ubiquitous pyridine dinucleotide coenzyme found in all living cells. Structurally, it consists of a nicotinamide riboside moiety linked via a pyrophosphate bridge to an adenosine monophosphate moiety. The molecule functions as a soluble electron carrier in numerous dehydrogenase-catalysed oxidation-reduction reactions, cycling between the oxidised (NAD+) and reduced (NADH) forms. Beyond its redox role, NAD+ serves as a substrate for ADP-ribosylation reactions, poly(ADP-ribose) polymerase (PARP) activity, and cyclic ADP-ribose synthesis. Knowlux supplies NAD+ as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished food or supplement product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes NAD+ as a central metabolite in cellular energy metabolism and a substrate for sirtuin and PARP family enzymes. Declining NAD+ levels have been observed in ageing and metabolic stress models, and oral NAD+ supplementation has been investigated in research settings for effects on fatigue and metabolic parameters. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of NAD+ for anti-aging, longevity, energy enhancement, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for NAD+/NADH redox pair analytical method development

• In vitro dehydrogenase and oxidoreductase enzyme assays

• Sirtuin and PARP activity research models

• Cellular energy metabolism and mitochondrial function studies

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. NAD+ is sold as a dietary supplement ingredient in some jurisdictions and is regulated differently across markets; customs authorities in certain countries have flagged NAD+ for enhanced scrutiny when presented as a food or supplement ingredient. Those regulatory positions attach to compliant food- and supplement-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.