Nicotinamide Riboside Chloride (NRC) | CAS 23111-00-4 | NAD+ Precursor (Research Use Only) | Knowlux

Product Description

Nicotinamide Riboside Chloride, CAS 23111-00-4, is a synthetic pyridinium riboside salt supplied by Knowlux for laboratory research use. It is also known as NRC, NR-Cl, or nicotinamide riboside chloride, and is the chloride salt form of nicotinamide riboside (NR), a naturally occurring vitamin B3 derivative and NAD+ precursor. The molecular formula is C11H15ClN2O5 and the molecular weight is 290.70 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Form and identity clarification: CAS 23111-00-4 is consistently recorded across PubChem, Sigma-Aldrich and MedChemExpress as the chloride salt of nicotinamide riboside. The free base form (nicotinamide riboside) is a distinct entity; Knowlux supplies the chloride salt explicitly and declares the counter-ion on each COA. Commercial listings frequently describe the material as food grade or supplement grade; those designations attach to compliant food-supply chains and do not apply to this research-grade lot.

Product Parameters

Product Details

1. Overview

Nicotinamide Riboside Chloride is the chloride salt of nicotinamide riboside (NR), a pyridine nucleoside that serves as a precursor to nicotinamide adenine dinucleotide (NAD+). NR was originally identified as a nutrient in milk and has since been studied extensively in cellular metabolism research. The chloride salt form is the commercially relevant solid form, offering improved crystallinity and handling stability relative to the free base. Knowlux supplies NRC as a research-grade material for laboratory and analytical use; this supply is not intended for human consumption and does not constitute a finished food or supplement product.

2. Research Context (Not a Therapeutic Claim)

Published literature describes nicotinamide riboside as an orally active NAD+ precursor that increases NAD+ levels and activates sirtuin pathways (SIRT1 and SIRT3) in preclinical and clinical research models. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of NRC for anti-aging, longevity, NAD+ boosting, or any health benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for NAD+ precursor analytical method development

• In vitro NAD+ biosynthesis and cellular metabolism studies

• Sirtuin activation and mitochondrial function research models

• LC-MS and biochemical assay calibrators

• Stability and formulation screening for pyridinium salt actives

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Nicotinamide riboside chloride has received GRAS status in the United States (GRN 635, for specific food applications) and is authorised as a novel food in the European Union (Commission Implementing Regulation (EU) 2020/16, up to 300 mg/day for healthy adults). Those regulatory positions attach to compliant food- and supplement-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.