Biotinoyl Tripeptide-1 (Biotin-GHK) | CAS 299157-54-3 | Cosmetic Tripeptide (Research Use Only) | Knowlux

Product Description

Biotinoyl Tripeptide-1, CAS 299157-54-3, is a synthetic biotin-conjugated tripeptide supplied by Knowlux for laboratory research use. It is also known by the synonyms Biotin-GHK, Procapil, and Biotinyl-GHK tripeptide. The peptide consists of a biotin moiety covalently linked to the N-terminus of the Gly-His-Lys sequence, corresponding to the molecular formula C24H38N8O6S and molecular weight 566.67 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and formula clarification: Multiple authoritative sources confirm the formula C24H38N8O6S and molecular weight 566.67 for Biotinoyl Tripeptide-1. One supplier datasheet lists C24H38N6O6S (566.7 Da) with the sequence Biotin-Gly-His-Lys; the difference in nitrogen count likely reflects a typographical variation in that single source, as the sequence and mass are otherwise consistent with the mainstream C24H38N8O6S assignment. Knowlux reports the formula consistent with ChemicalBook, MedChemExpress and GuideChem records.

Product Parameters

Product Details

1. Overview

Biotinoyl Tripeptide-1 is a biotinylated derivative of the GHK tripeptide (Gly-His-Lys), a sequence found in human plasma and studied for its role in tissue remodelling. The covalent attachment of biotin to the N-terminus creates a molecule that combines the copper-binding and matrix-stimulating properties of GHK with the high-affinity biotin-avidin interaction, making it a useful tool for detection and localisation studies in research settings. It is used in cosmetic ingredient research as a reference peptide for studies on hair follicle biology and scalp condition. Knowlux supplies Biotinoyl Tripeptide-1 as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic product.

2. Mechanism of Action (Research Context)

Published cosmetic research describes Biotinoyl Tripeptide-1 as a peptide that combines the biological activities of the GHK sequence with the structural properties of biotin. The GHK moiety is reported to stimulate collagen and glycosaminoglycan synthesis and to modulate inflammatory pathways in tissue-remodelling models. The biotin component is proposed to support keratin infrastructure and hair follicle anchoring, although direct published data on the biotin-GHK conjugate specifically is limited compared with the extensive literature on GHK alone. These descriptions are derived from published research on related peptides and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Biotinoyl Tripeptide-1 for hair growth, anti-hair loss, or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for biotinylated peptide analytical method development

• In vitro biotin-avidin detection and localisation studies

• GHK-related extracellular matrix and collagen synthesis research models

• Hair follicle biology and scalp research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C or -80 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, acetate content report, biotin content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Biotinoyl Tripeptide-1 is used as a cosmetic ingredient in some jurisdictions; that use and regulatory position attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Mechanism statements derived from cosmetic research are scientific background only and do not constitute medical advice, a cosmetic claim, or dosing guidance.