Nonapeptide-1 (Melanostatine-5) | CAS 158563-45-2 | Cosmetic Peptide (Research Use Only) | Knowlux

Product Description

Nonapeptide-1, CAS 158563-45-2, is a synthetic nonapeptide supplied by Knowlux for laboratory research use. It is also known by the brand name Melanostatine-5 and the INCI designation Nonapeptide-1. The peptide sequence is H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, incorporating D-phenylalanine and D-tryptophan residues that contribute to its stability profile. The molecular formula is C61H87N15O9S and the molecular weight is 1206.50 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and form clarification: NCATS Inxight Drugs records CAS 158563-45-2 under the validated UNII 64W45420K5, with the systematic name confirming the sequence H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2. Commercial listings consistently report the same molecular formula C61H87N15O9S and molecular weight approximately 1206.5. Counter-ion (acetate) content is declared on each COA, as commercial lots typically contain residual acetate from purification.

Product Parameters

Product Details

1. Overview

Nonapeptide-1 is a synthetic nonapeptide designed as an analogue of the pituitary hormone melanostatin (melanocyte-inhibiting factor). The sequence incorporates two D-amino acids (D-Phe and D-Trp) and a C-terminal amide, modifications intended to enhance stability against enzymatic degradation relative to the native hormone. It is used in cosmetic ingredient research as a reference peptide for studies on melanogenesis and pigmentation pathways. Knowlux supplies Nonapeptide-1 as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic product.

2. Mechanism of Action (Research Context)

Published cosmetic research describes Nonapeptide-1 as a peptide that interacts with the melanocortin system. It is reported to act as an antagonist at the melanocortin-1 receptor (MC1R) on melanocytes, competing with alpha-melanocyte-stimulating hormone (alpha-MSH) for receptor binding. By blocking MC1R activation, the peptide is proposed to attenuate the downstream signalling cascade (including tyrosinase activation) that leads to melanin synthesis, thereby reducing melanin production in research models. These descriptions are derived from published cosmetic research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Nonapeptide-1 for skin whitening, lightening, or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for cosmetic peptide analytical method development

• In vitro melanocortin receptor binding and functional assay development

• Melanogenesis and pigmentation pathway research models

• Cosmetic formulation stability and compatibility screening

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, acetate content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Nonapeptide-1 is used as a cosmetic ingredient in some jurisdictions; that use and regulatory position attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Mechanism statements derived from cosmetic research are scientific background only and do not constitute medical advice, a cosmetic claim, or dosing guidance.