Pentapeptide-18 (Leuphasyl) | CAS 64963-01-5 | Cosmetic Pentapeptide (Research Use Only) | Knowlux

Product Description

Pentapeptide-18, CAS 64963-01-5, is a synthetic pentapeptide supplied by Knowlux for laboratory research use. It is also known by the trade name Leuphasyl and the systematic sequence H-Tyr-D-Ala-Gly-Phe-Leu-OH. The peptide is an analogue of leucine-enkephalin with a D-alanine substitution at position 2, a modification that confers resistance to enzymatic degradation. The molecular formula is C29H39N5O7 and the molecular weight is 569.6 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity clarification: Pentapeptide-18 is frequently listed under the synonym (D-Ala2)-Leucine-Enkephalin or DADLE in supplier catalogs. While the sequence is identical, DADLE is a research tool used in opioid receptor studies, whereas Pentapeptide-18 is the INCI designation used in cosmetic ingredient research. Knowlux supplies the material under the Pentapeptide-18 designation; the sequence and CAS are the same. Counter-ion (acetate) content is declared on each COA, as commercial lots typically contain residual acetate from purification.

Product Parameters

Product Details

1. Overview

Pentapeptide-18 (Leuphasyl) is a synthetic pentapeptide modelled on the endogenous opioid peptide leucine-enkephalin. The substitution of L-alanine with D-alanine at position 2 is a deliberate design feature that protects the peptide from rapid peptidase cleavage, extending its stability in formulation research contexts. It is used in cosmetic ingredient research as a reference peptide for studies on neurotransmitter release and skin-aging pathways. Knowlux supplies Pentapeptide-18 as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic product.

2. Mechanism of Action (Research Context)

Published cosmetic research describes Pentapeptide-18 as a peptide that modulates neurotransmitter release at the presynaptic level. It is reported to influence the SNARE complex-mediated fusion of vesicles with the cellular membrane, thereby attenuating acetylcholine release and reducing muscle contraction associated with expression wrinkles. Beyond this neuromodulatory mechanism, a 2026 in silico study investigated interactions of Pentapeptide-18 with skin-aging-related signalling proteins including TGF-beta receptor-I, TNF-alpha, AKT-1 and MAPK14, suggesting potential biophysical interactions beyond the neuromodulatory pathway. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Pentapeptide-18 for wrinkle reduction, anti-aging, or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for cosmetic peptide analytical method development

• In vitro neurotransmitter release and SNARE complex research models

• Skin-aging pathway interaction studies (TGF-beta, TNF-alpha, MAPK signalling)

• Cosmetic formulation stability and compatibility screening

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, acetate content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Pentapeptide-18 is used as a cosmetic ingredient in some jurisdictions; that use and regulatory position attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Mechanism statements derived from cosmetic and in silico research are scientific background only and do not constitute medical advice, a cosmetic claim, or dosing guidance.