Syn-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate) | CAS 823202-99-9 | Cosmetic Peptide (Research Use Only) | Knowlux

Product Description

Syn-AKE, CAS 823202-99-9, is a synthetic tripeptide supplied by Knowlux for laboratory research use. Its full chemical name is Dipeptide Diaminobutyroyl Benzylamide Diacetate, and it is also known by the proprietary name Syn-Ake and the descriptive term snake tripeptide. The peptide sequence is beta-Ala-Pro-Dab-NH-Bzl, corresponding to beta-alanyl-L-prolyl-2,4-diamino-N-benzylbutanamide, formulated as the diacetate salt. The molecular formula is C19H29N5O3.2(C2H4O2) and the molecular weight is 495.58 g/mol (diacetate salt). Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Form and CAS clarification: CAS 823202-99-9 is consistently recorded across FDA UNII, GuideChem, ChemicalBook and InvivoChem as the diacetate salt of this peptide. The free base form corresponds to CAS 823202-98-8. A formula variant (C23H37N5O7, 495.577) appears in some supplier listings; this is the same diacetate salt expressed as a single combined molecular formula rather than the dot-separated form. Knowlux reports the dot-separated formula consistent with FDA UNII and GuideChem records and declares the counter-ion content on each COA.

Product Parameters

Product Details

1. Overview

Syn-AKE is a synthetic tripeptide designed to mimic the neuromuscular blocking activity of waglerin-1, a peptide found in the venom of the Temple Viper (Tropidolaemus wagleri). Despite the snake peptide marketing name, Syn-AKE is not derived from snake venom; it is a fully synthetic analogue engineered for cosmetic research applications. The proprietary name Syn-Ake was developed by Pentapharm (Sweden). Knowlux supplies Syn-AKE as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic product.

2. Mechanism of Action (Research Context)

Published cosmetic research describes Syn-AKE as a reversible antagonist of the muscle nicotinic acetylcholine receptor (nmAChR). It is reported to bind the epsilon subunit of the receptor, blocking acetylcholine binding and preventing sodium ion influx. Without depolarisation, nerve impulse transmission to the muscle is interrupted, and the muscle remains relaxed, a mechanism intended to reduce the appearance of dynamic wrinkles. This mechanism is described in the context of cosmetic ingredient research; it is not a therapeutic claim. These descriptions are derived from published research and supplier technical literature and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of Syn-AKE for wrinkle reduction, anti-aging, or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

4. Applications

• Reference standard for cosmetic peptide analytical method development

• In vitro nmAChR binding and functional assay development

• Cosmetic formulation stability and compatibility screening

• Comparative studies of waglerin-1 mimetic peptides

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, acetate content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Syn-AKE is used as a cosmetic ingredient in some jurisdictions; that use and regulatory position attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Mechanism statements derived from cosmetic research are scientific background only and do not constitute medical advice, a cosmetic claim, or dosing guidance.