Acetyl Octapeptide-3 (SNAP-8) | CAS 868844-74-0 | Cosmetic Octapeptide (Research Use Only) | Knowlux

Product Description

Acetyl Octapeptide-3, CAS 868844-74-0, is a synthetic octapeptide supplied by Knowlux for laboratory research use. It is also known by the proprietary name SNAP-8 and the INCI name Acetyl Octapeptide-3 (sometimes listed as Acetyl Octapeptide-8). The sequence is Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, an N-terminally acetylated and C-terminally amidated octapeptide that extends the hexapeptide Argireline sequence by two additional amino acids (Ala-Asp) at the C-terminus. The molecular formula is C41H70N16O16S and the molecular weight is 1075.16 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Sequence and form clarification: SNAP-8 is frequently described as an extended version of Acetyl Hexapeptide-3 (Argireline), with the added Ala-Asp residues intended to improve peptide stability and receptor interaction in cosmetic research models. The CAS 868844-74-0 is consistently recorded across ChemWhat, 10xchem, ChinaPeptides and multiple ChemicalBook supplier pages as this octapeptide sequence. Counter-ion (acetate) content is declared on each COA, as commercial lots typically contain residual acetate from purification.

Product Parameters

Product Details

1. Overview

Acetyl Octapeptide-3 (SNAP-8) is a synthetic cosmetic peptide designed as a structural analogue of the N-terminal domain of SNAP-25 (synaptosome-associated protein of 25 kDa). It is positioned in the cosmetic ingredient literature as an extended version of Acetyl Hexapeptide-3 (Argireline), with two additional amino acids (Ala-Asp) at the C-terminus intended to enhance peptide stability and interaction with the SNARE complex. Knowlux supplies SNAP-8 as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic product.

2. Mechanism of Action (Research Context)

Published cosmetic research describes Acetyl Octapeptide-3 as a peptide that mimics the N-terminal end of SNAP-25 and competes with it for binding to the SNARE protein complex. This competition is reported to inhibit the release of catecholamines (adrenaline and noradrenaline) at the neuromuscular junction, leading to reduced muscle contraction and a subsequent reduction in the appearance of dynamic wrinkles, particularly on the forehead and around the eyes. Unlike botulinum toxin, which cleaves SNAP-25, SNAP-8 is described as acting through competitive binding rather than proteolytic cleavage. These descriptions are derived from published cosmetic research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human application. Promotion of SNAP-8 for wrinkle reduction, anti-aging, or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for cosmetic peptide analytical method development

• In vitro SNARE complex binding and competition assay development

• Cosmetic formulation stability and compatibility screening

• Comparative studies of SNAP-25 mimetic peptides (Argireline vs SNAP-8)

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, acetate content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Acetyl Octapeptide-3 is used as a cosmetic ingredient in some jurisdictions; that use and regulatory position attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Mechanism statements derived from cosmetic research are scientific background only and do not constitute medical advice, a cosmetic claim, or dosing guidance.