AHK-Cu | CAS 49557-75-7 | Copper-Binding Tripeptide (Research Use Only) | Knowlux

Product Description

AHK-Cu, CAS 49557-75-7, is a synthetic copper-binding tripeptide supplied by Knowlux for laboratory research use. The sequence is Ala-His-Lys (AHK), an analogue of the GHK tripeptide in which the N-terminal glycine is replaced by alanine. In the copper complex form, the copper(II) ion coordinates through the histidine imidazole ring and the lysine amino group. The molecular formula of the free peptide is C14H24N6O4 and the molecular weight is 340.38 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Identity and CAS clarification: CAS 49557-75-7 is recorded across ChemicalBook, MedChemExpress, Macklin and Fluorochem as the free peptide Gly-His-Lys (GHK), with formula C14H24N6O4 and molecular weight 340.38. Several commercial listings label this CAS as "AHK-Cu" or "Copper Peptide". The "AHK" designation (Ala-His-Lys) and the copper-complex form are not the same entity as the free GHK peptide recorded under this CAS. Buyers should confirm the exact sequence, whether copper is present, and the counter-ion before purchase. Knowlux supplies the AHK-Cu designation as a research-grade copper-peptide preparation and declares the copper content and counter-ion on each COA.

Product Parameters

Product Details

1. Overview

AHK-Cu belongs to the copper-peptide family, in which a short histidine-containing peptide coordinates a copper(II) ion. The best-characterised member of this family is GHK-Cu (Gly-His-Lys copper complex); AHK-Cu differs by a single N-terminal residue (alanine in place of glycine). Both peptides share the histidine imidazole and lysine side chain that anchor the copper ion. Knowlux supplies AHK-Cu as a research-grade preparation for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic or drug product.

2. Mechanism of Action (Research Context)

Published research on copper-binding tripeptides has focused primarily on GHK-Cu. Reported activities in tissue-remodelling models include chemoattraction of repair cells, modulation of inflammatory cytokine levels, and effects on collagen and glycosaminoglycan synthesis. The AHK sequence shares the copper-coordinating residues with GHK, but direct published data on AHK-Cu specifically is limited. These descriptions are derived from published research on related copper-peptides and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of AHK-Cu for skin repair, anti-aging, hair growth or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for copper-peptide analytical method development

• In vitro extracellular matrix and collagen synthesis research models

• Copper transport and metallopeptide coordination studies

• Comparative studies of GHK-family copper peptides

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, copper content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Copper peptides are used as cosmetic ingredients in some jurisdictions and have been studied in dermatological research; those uses and regulatory positions attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. Research context statements are for scientific reference only and do not constitute medical advice, a cosmetic claim, or dosing guidance.