GHK-Cu (Copper Tripeptide-1) | CAS 89030-95-5 | Copper-Binding Tripeptide (Research Use Only) | Knowlux

Product Description

GHK-Cu, CAS 89030-95-5, is a synthetic copper-binding tripeptide supplied by Knowlux for laboratory research use. It is the copper(II) complex of the endogenous tripeptide glycyl-L-histidyl-L-lysine (GHK), with the copper ion coordinated primarily through the histidine imidazole ring and the lysine amino group. The molecular formula is C14H22CuN6O4 and the molecular weight is 401.91 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Formula and identity clarification: Commercial and database listings show minor variation in the reported formula and mass for GHK-Cu. InvivoChem COA and Biorbyt datasheet report C14H22CuN6O4 / 401.91; PubChem lists C14H24CuN6O4 / 403.92 for the Cu-GHK entity; Chemsigma lists C14H23CuN6O4 / 402.91. These differences reflect the treatment of the peptide's protonation state and the copper coordination sphere in the formula. Knowlux reports the formula and mass consistent with the InvivoChem and Biorbyt reference standard (C14H22CuN6O4, 401.91) and declares the counter-ion and assay basis on each COA.

Product Parameters

Product Details

1. Overview

GHK-Cu is the copper complex of the tripeptide glycyl-L-histidyl-L-lysine, a sequence found in human plasma and tissue. The peptide was first isolated from human albumin and has been studied for its role in tissue remodelling and wound repair. The copper ion is essential to the complex's biological profile; the peptide alone (without copper) and the copper-peptide complex exhibit different activities in published research models. Knowlux supplies GHK-Cu as a research-grade material for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished cosmetic or drug product.

2. Mechanism of Action (Research Context)

Published literature describes GHK-Cu as a complex that has been studied in in vitro and in vivo tissue-remodelling models. Reported activities include chemoattraction of repair cells such as macrophages and mast cells, anti-inflammatory effects (including suppression of free radicals and inflammatory cytokines), and increased synthesis of collagen, elastin and glycosaminoglycans. In a rat wound-chamber model, GHK-Cu injection produced a concentration-dependent increase in dry weight, DNA, total protein, collagen and glycosaminoglycan content, with collagen synthesis stimulated to a greater degree than non-collagen proteins. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of GHK-Cu for skin tightening, wrinkle reduction, hair growth or any cosmetic benefit is not supported by Knowlux and is inconsistent with research-use-only supply.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for copper-peptide analytical method development

• In vitro collagen synthesis and extracellular matrix research models

• Copper transport and metallopeptide coordination studies

• Wound healing and tissue remodelling research models

• LC-MS and biochemical assay calibrators

5. Packaging, Storage & Shipping

Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, copper content report. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. GHK-Cu is used as a cosmetic ingredient in some jurisdictions and has been studied in dermatological research; those uses and regulatory positions attach to compliant cosmetic-grade supply chains and do not apply to, and are not represented by, this research-grade lot. The published tissue-remodelling and wound-healing findings are scientific background only and do not constitute medical advice, a cosmetic claim, or dosing guidance.