Teriparatide Acetate | CAS 52232-67-4 / 99294-94-7 | Parathyroid Hormone Fragment (Research Use Only) | Knowlux

Product Description

Teriparatide Acetate, CAS 52232-67-4 (free peptide) / 99294-94-7 (acetate salt), is a synthetic 34-amino-acid peptide supplied by Knowlux for laboratory research use. It corresponds to the biologically active N-terminal fragment of human parathyroid hormone (PTH 1-34) and is formulated as the acetate salt for improved stability. The molecular formula is C181H291N55O51S2 and the molecular weight is 4117.8 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

CAS and form clarification: Commercial listings frequently conflate the free peptide CAS (52232-67-4) with the acetate salt CAS (99294-94-7). ChemicalBook lists Teriparatide acetate under both identifiers in different product entries. Knowlux specifies the acetate salt form explicitly and declares the counter-ion and assay basis on each COA.

Product Parameters

Product Details

1. Overview

Teriparatide is a recombinant or synthetic fragment of human parathyroid hormone comprising the first 34 amino acids of the native 84-amino-acid sequence. This fragment retains the bone-anabolic activity of full-length PTH and was the first FDA-approved agent in the bone-formation class for osteoporosis treatment. The acetate salt form is used in the commercial injectable product and is the form supplied by Knowlux for research use. Unlike bisphosphonates, which inhibit bone resorption, teriparatide stimulates osteoblast activity and new bone formation, making it a distinct pharmacological tool for studying bone metabolism.

2. Mechanism of Action

Teriparatide binds the PTH/PTHrP receptor (PTH1R), a class B G protein-coupled receptor expressed on osteoblasts and renal tubular cells. Intermittent administration produces an anabolic effect on bone: it preferentially stimulates osteoblast-mediated bone formation over osteoclast-mediated resorption, leading to increased bone mineral density and improved trabecular microarchitecture. The N-terminal residues (Ser1-Val2) are critical for receptor activation; truncation or modification of this region abolishes bioactivity. In research settings, teriparatide is used as a reference PTH analogue for PTH1R binding studies, osteoblast differentiation assays, and bone metabolism model research.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for PTH analogue analytical methods

• PTH1R binding and functional assay development

• Osteoblast differentiation and bone formation research models

• Formulation development for injectable PTH peptides

• LC-MS, immunoassay and bioassay calibrators

5. Packaging, Storage & Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification, oxidation product report. Regulatory packages (specification summaries, audit support) available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Teriparatide is approved as a prescription medicine in many jurisdictions for osteoporosis; that regulatory status is specific to the approved pharmaceutical products and does not extend to this research-grade supply as sold by Knowlux. Teriparatide carries a boxed warning regarding osteosarcoma risk in rats; this warning applies to the approved drug product and is noted here for reference only. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.