Octreotide Acetate | CAS 83150-76-9 / 79517-01-4 | Somatostatin Analogue (Research Use Only) | Knowlux

Product Description

Octreotide Acetate, CAS 83150-76-9 (free peptide) / 79517-01-4 (acetate salt), is a synthetic cyclic octapeptide analogue of somatostatin supplied by Knowlux for laboratory research use. It is a long-acting somatostatin receptor agonist with the sequence D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol, cyclised via a disulfide bridge between Cys2 and Cys7. The molecular formula for the acetate salt is C51H70N10O12S2 and the molecular weight is 1079.29 g/mol (acetate form). Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

CAS and form clarification: Commercial listings frequently conflate the free peptide CAS (83150-76-9) with the acetate salt CAS (79517-01-4). Sigma-Aldrich lists octreotide acetate under 79517-01-4 with formula C49H66N10O10S2 (free base basis, 1019.24 g/mol), while MedChemExpress lists the acetate salt as C51H70N10O12S2 (1079.29 g/mol). The difference reflects whether the acetic acid counter-ion is counted. Knowlux declares the counter-ion and assay basis on each COA.

Product Parameters

Product Details

1. Overview

Octreotide is a synthetic octapeptide that mimics the pharmacological actions of somatostatin but has a substantially longer plasma half-life (approximately 1-2 hours versus a few minutes for native somatostatin). It was developed by Sandoz and approved under the brand name Sandostatin for acromegaly, carcinoid syndrome, VIPomas, and other neuroendocrine tumours. The molecule incorporates D-amino acids at positions 1 and 4 and a C-terminal threoninol, modifications that confer resistance to enzymatic degradation. Knowlux supplies octreotide acetate as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug product.

2. Mechanism of Action

Octreotide binds with high affinity to somatostatin receptors (SSTR2 and SSTR5 primarily), which are G protein-coupled receptors expressed on neuroendocrine cells, pituitary somatotrophs, and gastrointestinal enterochromaffin-like cells. Receptor activation inhibits adenylyl cyclase and reduces intracellular calcium, leading to suppression of hormone secretion including growth hormone, glucagon, insulin, gastrin, vasoactive intestinal peptide (VIP), and serotonin. In research settings, octreotide is used as a reference somatostatin analogue for receptor binding studies, hormone secretion assays, and neuroendocrine tumour model research. The acetate salt form improves aqueous solubility relative to the free peptide.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for somatostatin analogue analytical methods

• SSTR binding and functional assay development

• Hormone secretion inhibition studies in neuroendocrine models

• Formulation development for long-acting injectable peptides

• LC-MS, immunoassay and bioassay calibrators

5. Packaging, Storage & Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Octreotide is approved as a prescription medicine (Sandostatin, Sandostatin LAR) in many jurisdictions for acromegaly and neuroendocrine tumours; that regulatory status is specific to the approved pharmaceutical products and does not extend to this research-grade supply as sold by Knowlux. Octreotide acetate is classified under GHS as H315 (skin irritation) and H319 (serious eye irritation). Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.