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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：67727-97-3
- Createtime： 2026-11-11
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | White Powder |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C16H30N4O4 |
| Sample Available | Yes |
KPV (Lys-Pro-Val) | CAS 67727-97-3 | Anti-Inflammatory Tripeptide (Research Use Only) | Knowlux
Product Description
KPV, CAS 67727-97-3, is a synthetic tripeptide supplied by Knowlux for laboratory research use. Its sequence is H-Lys-Pro-Val-OH, corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH, residues 11-13). The molecular formula is C16H30N4O4 and the molecular weight is 342.43 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
CAS and form clarification: CAS 67727-97-3 is consistently recorded across ChemicalBook, Creative Peptides and MSDS documents as the free acid form of KPV (H-Lys-Pro-Val-OH), with molecular formula C16H30N4O4 and molecular weight 342.43. A separate PubChem entry for the N-acetylated, D-amino acid, C-amidated analogue (Ac-D-Lys-Pro-D-Val-NH2, CID 129362694) has a different molecular weight (383.5 g/mol) and is not the same substance. Commercial listings should be checked for counter-ion and terminal modification before purchase.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | KPV |
| Synonyms | Lys-Pro-Val; alpha-MSH (11-13) (free acid); H-Lys-Pro-Val-OH |
| CAS No. | 67727-97-3 |
| Molecular Formula | C16H30N4O4 |
| Molecular Weight | 342.43 g/mol |
| Sequence | H-Lys-Pro-Val-OH |
| Sequence Length | 3 amino acids |
| Key Structural Features | Free N-terminus and free C-terminus (free acid form); no acetylation or amidation |
| Appearance | White to off-white powder |
| Solubility | Soluble in water and aqueous buffers |
| Purity | >=98.0% (HPLC); >=99.0% available on request |
| Identity | Confirmed by LC-MS and peptide mapping |
| Grade | Research grade |
| Counter-ion | Acetate (lot-specific, declared on COA) |
| Moisture | <=8.0% (Karl Fischer) |
| Storage | -20 C, protected from light and moisture; desiccated |
| HS Code | 2937.19.00 |
| Packaging | 1 mg / 5 mg / 10 mg / 50 mg / 100 mg vial; bulk on request |
| MOQ | 10 mg (research grade); 100 mg (bulk) |
| Supply Ability | Milligram to gram scale |
| Application | Laboratory research use only |
| Origin | China |
Product Details
1. Overview
KPV is the minimal C-terminal tripeptide sequence of alpha-MSH, comprising lysine, proline and valine. Unlike the core melanocortin sequence (His-Phe-Arg-Trp), KPV does not require the melanocortin receptor pharmacophore for its anti-inflammatory activity. Published studies indicate that KPV exerts its effects through a mechanism distinct from classical melanocortin receptor agonism, likely involving direct modulation of inflammatory cytokine signalling. Knowlux supplies KPV as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug product.
2. Mechanism of Action
Published research indicates that KPV reduces inflammatory responses through mechanisms that appear independent of melanocortin receptor activation. In a crystal-induced peritonitis model, KPV inhibited polymorphonuclear leukocyte migration, but this effect was not blocked by an MC3/4-R antagonist, and KPV failed to increase cAMP in macrophages, suggesting a non-receptor-mediated pathway. In keratinocyte studies, KPV inhibited PM10-induced reactive oxygen species production, suppressed ERK/p38 MAPK phosphorylation, and reduced NF-kappaB activation, thereby decreasing IL-1beta secretion and apoptotic cell death. These descriptions are derived from published research and are provided for scientific reference only.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity | RP-HPLC |
| Identity & molecular mass | LC-MS (deconvoluted) |
| Sequence confirmation | Peptide mapping / amino acid analysis |
| Counter-ion content | Ion chromatography (acetate) |
| Moisture | Karl Fischer |
| Appearance | Visual |
| Related substances | RP-HPLC |
| Microbial limits | Membrane filtration (on request) |
Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.
4. Applications
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Reference standard for KPV analytical method development
-
In vitro inflammation and oxidative stress research models
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Keratinocyte and skin biology research
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NF-kappaB and MAPK signalling pathway studies
-
LC-MS and immunoassay calibrators
5. Packaging, Storage & Shipping
Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. KPV is an endogenous peptide fragment and is not approved as a therapeutic product in any jurisdiction. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
