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- Brand：Knowlux
- Model：Bottle/Drum/Customized to your needs
- Purity：99%
- Cas：597562-32-8
- Createtime： 2026-11-11
- Updatetime： 2026-11-03
| useage | Laboratory research，Food/nutraceutical industry (regulated forms only)，Cosmetics |
| deliveryInfo | |
| sample availble | yes |
| appearance | White powder |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C205H341N61O52 |
LL-37 (Human) | CAS 597562-32-8 | Cathelicidin Antimicrobial Peptide (Research Use Only) | Knowlux
Product Description
LL-37 (human), CAS 597562-32-8, is a synthetic 37-amino-acid antimicrobial peptide supplied by Knowlux for laboratory research use. It corresponds to the mature C-terminal peptide derived from the human cathelicidin precursor hCAP-18, and is the only cathelicidin peptide found in humans. The peptide is C-terminally amidated and adopts an amphipathic alpha-helical structure upon membrane interaction. The molecular formula is C205H341N61O52 and the molecular weight is 4492.28 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
CAS clarification: CAS 597562-32-8 is frequently confused with 154947-66-7 in commercial listings. 597562-32-8 corresponds to the C-terminally amidated form (LL-37 amide), while 154947-66-7 is associated with the free-acid form in some supplier records. Knowlux specifies the amide form explicitly and declares the counter-ion per lot.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | LL-37 (human) |
| Synonyms | LL-37 amide; Cathelicidin; hCAP18; Human cationic antimicrobial protein 18; CAMP |
| CAS No. | 597562-32-8 |
| Related CAS | 154947-66-7 (free acid form, listed by some suppliers) |
| Molecular Formula | C205H341N61O52 |
| Molecular Weight | 4492.28 g/mol |
| Sequence | H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2 |
| Sequence Length | 37 amino acids, C-terminally amidated |
| Key Structural Features | Amphipathic alpha-helix; net charge +6 at pH 7; isoelectric point approximately 11.1 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water; soluble in ethanol (90 mg/mL) |
| Purity | >=98.0% (HPLC); >=99.0% available on request |
| Identity | Confirmed by LC-MS and peptide mapping |
| Grade | Research grade |
| Counter-ion | TFA or acetate (lot-specific, declared on COA) |
| Moisture | <=8.0% (Karl Fischer) |
| Storage | -20 C (short-term) or -80 C (long-term), protected from light and moisture |
| HS Code | 2937.19.00 |
| Packaging | 1 mg / 5 mg / 10 mg / 50 mg / 100 mg vial; bulk on request |
| MOQ | 10 mg (research grade); 100 mg (bulk) |
| Supply Ability | Milligram to gram scale |
| Application | Laboratory research use only |
| Origin | China |
Product Details
1. Overview
LL-37 is the sole human member of the cathelicidin family of host defence peptides. It is produced by proteolytic cleavage of the 18-kDa precursor protein hCAP-18, which is stored in neutrophil granules and expressed inducibly by epithelial cells, keratinocytes and macrophages. The mature peptide is 37 amino acids long, begins with two leucine residues (hence the name), and is C-terminally amidated in its native form. LL-37 is multifunctional: beyond direct antimicrobial activity, it modulates immune cell recruitment, angiogenesis and wound healing processes. Knowlux supplies LL-37 as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug product.
2. Mechanism of Action
LL-37 exerts antimicrobial activity primarily through membrane disruption. Its amphipathic alpha-helical structure allows it to insert into lipid bilayers, forming pores or destabilising membrane integrity in a manner that is less susceptible to conventional resistance mechanisms than many small-molecule antibiotics. Beyond direct killing, LL-37 binds and activates multiple receptors on host cells depending on cell type, producing effects that include chemotaxis, cytokine release, epithelial and keratinocyte proliferation/migration, and endothelial progenitor recruitment for angiogenesis. In published wound-healing models, LL-37 has been shown to promote re-epithelialisation and vascularisation. These descriptions are derived from published research and are provided for scientific reference only.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity | RP-HPLC |
| Identity & molecular mass | LC-MS (deconvoluted) |
| Sequence confirmation | Peptide mapping / amino acid analysis |
| Counter-ion content | Ion chromatography (TFA or acetate) |
| Moisture | Karl Fischer |
| Appearance | Visual |
| Related substances | RP-HPLC |
| Microbial limits | Membrane filtration (on request) |
Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.
4. Applications
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Reference standard for cathelicidin antimicrobial peptide analytical methods
-
Antimicrobial susceptibility and membrane interaction studies
-
Innate immunity and host defence peptide research models
-
Wound healing and angiogenesis research models
-
LC-MS and immunoassay calibrators
5. Packaging, Storage & Shipping
Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C or -80 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. LL-37 is an endogenous human peptide and is not approved as a therapeutic product in any jurisdiction. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
