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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：736992-21-5
- Createtime： 2026-11-11
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | White Powder |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C32H49N9O5 |
| Sample Available | Yes |
Elamipretide (SS-31) | CAS 736992-21-5 | Mitochondria-Targeted Tetrapeptide (Research Use Only) | Knowlux
Product Description
Elamipretide, CAS 736992-21-5, is a synthetic mitochondria-targeted tetrapeptide supplied by Knowlux for laboratory research use. It is a cell-permeable peptide with the sequence D-Arg-Dmt-Lys-Phe-NH2, where Dmt represents 2',6'-dimethyltyrosine, and is also known by the development codes SS-31, MTP-131, and Bendavia. The molecular formula is C32H49N9O5 and the molecular weight is 639.79 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Elamipretide |
| Synonyms | SS-31; MTP-131; Bendavia; RX-31; D-Arg-Dmt-Lys-Phe-NH2 |
| CAS No. | 736992-21-5 |
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | 639.79 g/mol |
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2',6'-dimethyltyrosine) |
| Sequence Length | 4 amino acids, C-terminally amidated |
| Key Structural Features | D-arginine at N-terminus; dimethyltyrosine (Dmt) residue; C-terminal phenylalaninamide |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water and aqueous buffers |
| Purity | >=98.0% (HPLC); >=99.0% available on request |
| Identity | Confirmed by LC-MS and peptide mapping |
| Grade | Research grade |
| Counter-ion | Acetate or TFA (lot-specific, declared on COA) |
| Moisture | <=8.0% (Karl Fischer) |
| Storage | -20 C (powder, long-term); 4 C (short-term); protect from light and moisture |
| HS Code | 2937.19.00 |
| Packaging | 1 mg / 5 mg / 10 mg / 50 mg / 100 mg vial; bulk on request |
| MOQ | 10 mg (research grade); 100 mg (bulk) |
| Supply Ability | Milligram to gram scale |
| Application | Laboratory research use only |
| Origin | China |
Product Details
1. Overview
Elamipretide is a mitochondria-targeted tetrapeptide developed from structure-activity studies on opioid peptides, with the goal of achieving cell permeability and mitochondrial localisation without opioid receptor activity. It is also known by the development codes SS-31 (the research peptide), MTP-131 (the clinical development code), and Bendavia (an earlier proposed brand name). The molecule is short, stable, and designed to concentrate at the inner mitochondrial membrane, where it interacts with cardiolipin.
2. Mechanism of Action
Elamipretide binds to cardiolipin, a phospholipid found almost exclusively on the inner mitochondrial membrane. Cardiolipin is essential for the stability and function of respiratory chain supercomplexes; its oxidation or depletion impairs electron transport and increases reactive oxygen species production. By binding cardiolipin, elamipretide stabilises respiratory chain supercomplexes, enhances electron transport efficiency, and reduces reactive oxygen species generation. In published preclinical models, these effects have been associated with improved mitochondrial function in cardiac, renal, and neuronal tissues. The sequence D-Arg-Dmt-Lys-Phe-NH2 is critical to this activity: the D-arginine provides cell permeability, the Dmt residue contributes antioxidant capacity, and the C-terminal amide enhances stability.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity | RP-HPLC |
| Identity & molecular mass | LC-MS (deconvoluted) |
| Sequence confirmation | Peptide mapping / amino acid analysis |
| Counter-ion content | Ion chromatography (acetate or TFA) |
| Moisture | Karl Fischer |
| Appearance | Visual |
| Related substances | RP-HPLC |
| Microbial limits | Membrane filtration (on request) |
4. Applications
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Reference standard for mitochondria-targeted peptide analytical methods
-
Cardiolipin binding and mitochondrial membrane interaction studies
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Cell permeability and mitochondrial localisation assay development
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Oxidative stress and mitochondrial function research models
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LC-MS and immunoassay calibrators
5. Packaging, Storage & Shipping
Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Elamipretide received accelerated approval from the US FDA in September 2025 under the brand name FORZINITY for Barth syndrome in patients weighing at least 30 kg; that approval is specific to the finished pharmaceutical product and does not extend to this research-grade supply as sold by Knowlux. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
