N-Acetyl Semax Amidate | CAS 1265823-54-2 | Semax Analogue Heptapeptide (Research Use Only) | Knowlux

Product Description

N-Acetyl Semax Amidate, CAS 1265823-54-2, is a synthetic heptapeptide analogue of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) supplied by Knowlux for laboratory research use. It is a terminally blocked peptide with the sequence Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2, modified by N-terminal acetylation and C-terminal amidation. The molecular formula is C39H54N10O10S and the molecular weight is 854.97 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

CAS Clarification: CAS 1265823-54-2 is the correct registry number. Some suppliers list CAS 2920938-90-3 as an alternate registry. Several ChemicalBook listings misattribute CAS 4037-01-8 to this product. Confirm identity with the supplier before purchase.

Product Parameters

Item	Specification
Product Name	N-Acetyl Semax Amidate
Synonyms	NA-Semax Amidate; Ac-MEHFPGP-NH2
CAS No.	1265823-54-2 (alternative: 2920938-90-3)
Molecular Formula	C39H54N10O10S
Molecular Weight	854.97 g/mol
Sequence (1-letter)	Ac-MEHFPGP-NH2
Sequence (3-letter)	Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
Sequence Length	7 amino acids
Key Structural Features	N-terminal acetylation; C-terminal amidation; free thioether (Met); imidazole ring (His)
Appearance	White to off-white lyophilized powder
Solubility	Soluble in DMSO (up to 100 mg/mL); limited aqueous solubility
Purity	>=98.0% (HPLC); >=99.0% available on request
Identity	Confirmed by LC-MS
Grade	Research grade
Counter-ion	Lot-specific (declared on COA)
Moisture	<=8.0% (Karl Fischer)
Storage	-20C, protected from light and moisture; desiccated; avoid freeze-thaw cycles
Packaging	1 mg / 5 mg / 10 mg / 50 mg / 100 mg vial; bulk on request
MOQ	10 mg (research grade); 100 mg (bulk)
Supply Ability	Milligram to gram scale
Application	Laboratory research use only
Origin	China

Product Details

1. Overview

N-Acetyl Semax Amidate is a terminally blocked analogue of the endogenous heptapeptide Semax, engineered for enhanced metabolic stability. The N-acetyl and C-amide modifications protect both termini of the peptide backbone against exopeptidase degradation, distinguishing its stability profile from unmodified Semax in receptor and cell-signalling studies. Knowlux supplies this compound as a research-grade peptide; it is not approved as a therapeutic agent in any jurisdiction, and supply is restricted to laboratory research channels.

2. Structural Profile

The peptide backbone contains seven amino acids with a free thioether side chain on methionine and an imidazole ring on histidine. The C-terminal amide replaces the free carboxylate, eliminating one negative charge at physiological pH. This charge alteration may influence blood-brain barrier permeability characteristics in experimental models. MedChemExpress describes the compound as the N-acetylated and C-amidated derivative of Semax for use in aqueous nasal formulation research.

3. Research Applications

Published preclinical characterizations describe the following research activities:

• Upregulation of BDNF and NGF expression in neuronal cell models

• Inhibition of neuronal apoptosis in oxidative stress paradigms

• Attenuation of glutamate-induced excitotoxicity

• Reference standard development for HPLC and LC-MS analytical methods

• Biochemical studies of peptide stability and terminal modification effects

These descriptions are derived from published research and are provided for scientific reference only. They are derived from in vitro and preclinical investigations and do not establish clinical efficacy or safety.

Quality Control

Solubility and Handling

Solubility: DMSO is the preferred solvent for stock preparation, with reported solubility up to 100 mg/mL (116.96 mM) requiring sonication. Aqueous solubility is limited; for aqueous buffers, sonication and gentle warming may be necessary. Prepare solutions fresh and aliquot to avoid repeated freeze-thaw cycles.

Handling Precautions: Use powder-handling containment (glove box or fume hood with particulate control). Avoid inhalation of fine powder. Wear nitrile gloves, lab coat, and eye protection. Follow institutional chemical hygiene plans for research peptides.

Storage and Stability

Packaging and Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

Documentation Support

Per lot: COA, MSDS, certificate of origin, HPLC chromatogram, and mass spectrometry data. Regulatory packages (specification summaries, audit support) and third-party inspection available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

FOR RESEARCH USE ONLY. NOT FOR HUMAN USE. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. N-Acetyl Semax Amidate is not approved as a medicinal product in any jurisdiction. The purchaser is responsible for verifying product specifications against their specific research requirements and for compliance with all applicable institutional, local, and national regulations governing research chemical acquisition, storage, and use. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.