Oxyntomodulin (Porcine, Bovine) | CAS 62340-29-8 | Dual GLP-1/Glucagon Receptor Agonist (Research Use Only) | Knowlux

Product Description

Oxyntomodulin (porcine, bovine), CAS 62340-29-8, is a synthetic 37-amino-acid peptide hormone supplied by Knowlux for laboratory research use. It corresponds to the full sequence of glucagon with an eight-amino-acid C-terminal extension (intervening peptide), and functions as a dual agonist at both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). The molecular formula is C192H295N59O60S and the molecular weight is 4421.86 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Product Parameters

Product Details

1. Overview

Oxyntomodulin is a 37-amino-acid peptide derived from the proglucagon precursor through post-translational processing by PC1/3, and is co-secreted from intestinal L-cells in response to food intake. Its sequence comprises the complete glucagon sequence plus an eight-amino-acid C-terminal extension. Unlike GLP-1, oxyntomodulin has no dedicated receptor; its biological effects are mediated through simultaneous activation of GLP-1R and GCGR. Native oxyntomodulin has a short plasma half-life of approximately 12 minutes due to rapid DPP-IV degradation and renal clearance, which has driven the development of longer-acting analogues for metabolic disease research. Knowlux supplies oxyntomodulin (porcine, bovine) as a research-grade peptide for laboratory and analytical use.

2. Mechanism of Action

Oxyntomodulin binds both GLP-1R and GCGR, combining the anorectic and insulinotropic effects of GLP-1R agonism with the energy-expenditure-promoting effects of GCGR activation. Preclinical studies indicate that the GCGR component is required for the weight-lowering effect: when GCGR activity is eliminated by a single amino acid substitution (OXM Q3E) while preserving GLP-1R activity, weight loss in diet-induced obese mice is abolished. In human studies, preprandial oxyntomodulin injections reduced energy intake by approximately 19-25% and produced a body weight reduction of 2.3 kg over 4 weeks compared with 0.5 kg in the placebo group. The balanced activation of both receptors is thought to allow the anabolic effects of GLP-1R to counteract the hyperglycaemic potential of GCGR activation, while preserving the catabolic and energy-expenditure effects of glucagon.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard and impurity studies for dual GLP-1R/GCGR agonist analytical methods

• GLP-1R and GCGR binding and functional assay development

• Formulation development for long-acting injectable peptides

• Metabolic disease model research, including appetite regulation, energy expenditure and glucose homeostasis studies

• LC-MS, immunoassay and bioassay calibrators

5. Packaging, Storage & Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Oxyntomodulin is an endogenous peptide hormone and is not approved as a therapeutic product in any jurisdiction. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.