Exenatide Acetate | CAS 141732-76-5 | GLP-1 Receptor Agonist (Research Use Only) | Knowlux

Product Description

Exenatide Acetate, CAS 141732-76-5, is a synthetic GLP-1 receptor agonist supplied by Knowlux for laboratory research use. It is the acetate salt form of exenatide (free base CAS 141758-74-9), a 39-amino-acid peptide originally isolated from the saliva of the Gila monster (Heloderma suspectum) and produced synthetically for research and pharmaceutical applications. The molecular formula for the acetate form is C186H286N50O62S and the molecular weight is 4246.62 g/mol; the free base corresponds to C184H282N50O60S and 4186.63 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Product Parameters

Product Details

1. Overview

Exenatide is a synthetic version of exendin-4, a peptide found in Gila monster venom that shares approximately 50% sequence homology with human GLP-1 but is resistant to DPP-4 degradation, giving it a substantially longer half-life than native GLP-1. It was approved by the FDA as Byetta (twice-daily injection) and later as Bydureon (once-weekly extended-release formulation) for glycaemic control in type 2 diabetes. Knowlux supplies exenatide acetate as a research-grade peptide for laboratory and analytical use; this supply is not intended for human administration and does not constitute a finished drug product.

2. Mechanism of Action

Exenatide binds and activates the GLP-1 receptor, producing glucose-dependent insulin secretion from pancreatic beta cells, suppression of glucagon release during hyperglycaemia, slowing of gastric emptying, and reduced food intake. The glucose-dependent nature of insulinotropic activity means that insulin secretion is stimulated only when blood glucose is elevated, reducing the risk of hypoglycaemia from GLP-1 agonism alone. In clinical studies, exenatide treatment has been associated with HbA1c reductions of approximately 0.8-1% and progressive weight loss.

3. Quality Control

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard and impurity studies for GLP-1 receptor agonist analytical methods

• GLP-1R binding and functional assay development

• Formulation development for long-acting injectable peptides

• Metabolic disease model research, including glucose homeostasis and appetite regulation studies

• LC-MS, immunoassay and bioassay calibrators

5. Packaging, Storage & Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger; dry ice for -20 C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Regulatory packages (specification summaries, audit support) available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Exenatide is approved as a prescription medicine (Byetta, Bydureon) in many jurisdictions for type 2 diabetes; that regulatory status is specific to the approved pharmaceutical products and does not extend to this research-grade supply as sold by Knowlux. Exenatide extended-release carries a boxed warning regarding thyroid C-cell tumours in rodents; this warning applies to the approved drug product and is noted here for reference only. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.