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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：65277-42-1
- Createtime： 2026-11-06
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | White to off-white crystalline powder, slightly hygroscopic |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1KG |
| Molecular Formula: | C26H28Cl2N4O4 |
| Sample Available | Yes |
Ketoconazole | CAS 65277-42-1 | Imidazole Antifungal (Research Use Only) | Knowlux
Product Description
Ketoconazole, CAS 65277-42-1, is a synthetic imidazole derivative supplied by Knowlux for laboratory and pharmaceutical research use. It is also known as Nizoral. The molecular formula is C26H28Cl2N4O4 and the molecular weight is 531.43 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Ketoconazole |
| Synonyms | Nizoral; cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine |
| CAS No. | 65277-42-1 |
| Molecular Formula | C26H28Cl2N4O4 |
| Molecular Weight | 531.43 g/mol |
| Chemical Name | cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine |
| Appearance | White to off-white crystalline powder |
| Melting Point | 146-152 C |
| Solubility | Insoluble in water; soluble in dichloromethane, methanol |
| Purity | >=98.0% (HPLC); >=99.0% available on request |
| Identity | Confirmed by HPLC and UV-Vis |
| Grade | Pharmaceutical research grade |
| Storage | 2-8 C, protected from light and moisture |
| Hazard Classification | Prescription drug substance; hepatotoxicity risk (FDA boxed warning for oral formulation) |
| HS Code | 2933.29.00 |
| Packaging | 5 g / 10 g / 50 g / 100 g / 1 kg foil bag or vial; bulk on request |
| MOQ | 10 g (research grade); 100 g (bulk) |
| Supply Ability | Gram to kilogram scale |
| Application | Laboratory and pharmaceutical research use only |
| Origin | China |
Product Details
1. Overview
Ketoconazole is a synthetic imidazole antifungal agent that was first approved by the FDA in 1981. It has been widely used in pharmaceutical research and clinical medicine for the treatment of fungal infections. Knowlux supplies ketoconazole as a research-grade material for laboratory and pharmaceutical research use; this supply is not intended for direct human or veterinary administration and does not constitute a finished drug product.
2. Research Context (Not a Therapeutic Claim)
Published literature describes ketoconazole as an imidazole derivative studied in in vitro and in vivo research models, with a mechanism involving inhibition of fungal cytochrome P450-dependent sterol synthesis. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application. Promotion of ketoconazole for antifungal treatment or any clinical indication is not supported by Knowlux and is inconsistent with research-use-only supply.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity | HPLC |
| Identity | HPLC retention time / UV-Vis spectrum |
| Appearance | Visual |
| Moisture | Karl Fischer |
| Related substances | HPLC |
| Residual solvents | GC (on request) |
| Heavy metals | ICP-MS (on request) |
Full COA, MSDS, and lot-specific chromatograms are issued with each shipment.
4. Applications
-
Reference standard for analytical method development
-
In vitro antifungal susceptibility and mechanism studies
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Pharmaceutical formulation and stability studies
-
LC-MS and biochemical assay calibrators
5. Packaging, Storage & Shipping
Powder: amber glass vial or high-barrier foil bag under nitrogen headspace, sealed with tamper-evident closure. Secondary packing: light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, residual solvent statement, heavy metal statement. Specification summaries and audit support available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for laboratory and pharmaceutical research use only. It is not for direct human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Ketoconazole is a prescription drug substance in many jurisdictions and carries an FDA boxed warning for hepatotoxicity in its oral formulation; those regulatory statuses are separate from this research-grade supply and do not extend to the product as sold by Knowlux. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
