Thymosin alpha-1 (Thymalfasin) | CAS 62304-98-7 | Immunomodulatory Peptide (Research Use Only) | Knowlux

Product Description

Thymosin alpha-1, CAS 62304-98-7, is a synthetic 28-amino-acid peptide supplied by Knowlux for laboratory research use. It is also known as Thymalfasin and corresponds to the N-terminal fragment of prothymosin alpha, with the sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. The molecular formula is C129H215N33O55 and the molecular weight is 3108.3 g/mol (free peptide). Each lot is released with a lot-specific COA, MSDS and full analytical traceability.

Product Parameters

Item	Specification
Product Name	Thymosin alpha-1
Synonyms	Thymalfasin; T-alpha-1; TA1; Zadaxin
CAS No.	62304-98-7
Molecular Formula	C129H215N33O55
Molecular Weight	3108.3 g/mol (free peptide)
Sequence	Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Sequence Length	28 amino acids, N-terminally acetylated
Appearance	White to off-white lyophilized powder
Purity	>=98.0% (HPLC); >=99.0% available on request
Identity	Confirmed by LC-MS and peptide mapping
Grade	Research grade
Counter-ion	Acetate (lot-specific, declared on COA)
Moisture	<=8.0% (Karl Fischer)
Storage	-20 C, protected from light and moisture; reconstituted solution 2-8 C, use within 7 days
HS Code	2937.19.00
Packaging	5 mg / 10 mg / 50 mg / 100 mg / 1 g vial; bulk and OEM on request
MOQ	10 mg (research grade); 1 g (bulk)
Supply Ability	Gram to kilogram scale
Application	Laboratory research use only
Origin	China

Product Details

1. Overview

Thymosin alpha-1 (thymalfasin) is a synthetic 28-amino-acid peptide corresponding to the N-terminal sequence of prothymosin alpha. It is approved in more than 35 countries under the brand name Zadaxin for indications including chronic hepatitis B and as a vaccine adjuvant, but it is not approved by the FDA for any indication in the United States. Knowlux supplies Thymosin alpha-1 as a research-grade peptide for laboratory and analytical use.

2. Research Context (Not a Therapeutic Claim)

Published literature describes Thymosin alpha-1 as an immunomodulatory peptide that has been studied in in vitro and in vivo research models, with proposed effects on T-cell maturation and cytokine production. These descriptions are derived from published research and are provided for scientific reference only. Knowlux makes no claims regarding the efficacy, safety, or suitability of this product for any human or veterinary application.

3. Quality Control

Test Item	Method
Purity	RP-HPLC
Identity & molecular mass	LC-MS (deconvoluted)
Amino acid composition	Amino acid analysis
N-terminal acetylation completeness	LC-MS / peptide mapping
Counter-ion content	Ion chromatography (acetate)
Moisture	Karl Fischer
Appearance	Visual
Related substances	RP-HPLC
Microbial limits	Membrane filtration (on request)

Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.

4. Applications

• Reference standard for analytical method development

• In vitro peptide stability and degradation studies

• Research on peptide structure-activity relationships

• LC-MS and immunoassay calibrators

5. Packaging, Storage & Shipping

Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.

6. Documentation Support

Per lot: COA, MSDS, certificate of origin, residual solvent statement, counter-ion specification. Specification summaries and audit support available on a project basis.

About Knowlux

Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.

Compliance Statement

This product is supplied for laboratory research use only. It is not for human or animal administration, not for diagnostic or therapeutic use, not for retail sale, and not for personal use. Thymosin alpha-1 is not FDA-approved for any indication in the United States; international approvals as thymalfasin (Zadaxin) are separate from this research-grade supply. Research context statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.