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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：204656-20-2
- Createtime： 2026-11-06
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | White Powder |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C172H265N43O51 |
| Sample Available | Yes |
Liraglutide (NN2211) | CAS 204656-20-2 | GLP-1 Receptor Agonist | Knowlux
Product Description
Liraglutide, CAS 204656-20-2, is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist supplied by Knowlux for research and development use. It is a synthetic 31-amino-acid peptide with a C16 fatty acid (palmitic acid) side chain conjugated via a gamma-glutamyl linker to Lys26, enabling reversible albumin binding and a prolonged half-life. The molecular formula is C172H265N43O51 and the molecular weight is 3751.20 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Liraglutide |
| Synonyms | NN2211; NNC 90-1170; Victoza |
| CAS No. | 204656-20-2 |
| Molecular Formula | C172H265N43O51 |
| Molecular Weight | 3751.20 g/mol |
| Sequence Length | 31 amino acids, lipidated |
| Key Structural Features | C16 palmitic acid via gamma-glutamyl linker on Lys26; Arg34 substitution |
| Sequence | H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(gamma-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
| Appearance | White to off-white lyophilized powder |
| Purity | >=98.0% (HPLC); >=99.0% available on request |
| Identity | Confirmed by LC-MS and peptide mapping |
| Grade | Research grade |
| Counter-ion | Acetate (lot-specific, declared on COA) |
| Moisture | <=10.0% (Karl Fischer) |
| Storage | 2-8 C, protected from light and moisture; reconstituted solution 2-8 C, use within 7 days |
| HS Code | 2937.19.00 |
| Packaging | 1 mg / 5 mg / 10 mg / 100 mg / 1 g vial; bulk and OEM on request |
| MOQ | 10 mg (research grade); 1 g (bulk) |
| Supply Ability | Gram to kilogram scale |
| Application | Pharmaceutical R&D |
| Origin | China |
Product Details
1. Overview
Liraglutide (NN2211) is a once-daily GLP-1 receptor agonist approved for the treatment of type 2 diabetes mellitus and, at a higher dose, for weight management. It shares 97% sequence homology with native human GLP-1 (7-37) and incorporates two key modifications: a C16 palmitic acid side chain attached via a gamma-glutamyl spacer at Lys26, and an Arg34 substitution. The fatty acid moiety confers reversible binding to serum albumin, protecting the molecule from DPP-4 degradation and extending its half-life to approximately 11-12 hours in humans, supporting once-daily subcutaneous administration.
2. Mechanism of Action
Liraglutide binds and activates the GLP-1 receptor on pancreatic beta-cells, stimulating glucose-dependent insulin secretion and suppressing glucagon release. It also slows gastric emptying and reduces appetite through central GLP-1 signalling. Because insulinotropic activity is glucose-dependent, the risk of hypoglycaemia from GLP-1 receptor agonism alone is low. The albumin-binding property of the C16 fatty acid side chain protects liraglutide from rapid DPP-4-mediated degradation, distinguishing it from native GLP-1, whose half-life is only 1.5-2 minutes.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity | RP-HPLC |
| Identity & molecular mass | LC-MS (deconvoluted) |
| Primary structure | Peptide mapping / amino acid analysis |
| Counter-ion content | Ion chromatography (acetate) |
| Moisture | Karl Fischer |
| Appearance | Visual |
| Related substances | RP-HPLC |
| Microbial limits | Membrane filtration (on request) |
Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.
4. Applications
-
Reference standard and impurity studies for GLP-1 receptor agonist analytical methods
-
GLP-1R binding, cAMP and beta-cell functional assay development
-
Formulation development for long-acting injectable peptides
-
Metabolic disease model research, including glucose homeostasis and appetite regulation studies
-
LC-MS, immunoassay and bioassay calibrators
5. Packaging, Storage & Shipping
Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Secondary packing: tamper-evident, light-protected carton with desiccant. Cold-chain shipping with validated gel packs and temperature logger. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, GMO/allergen-free statement, residual solvent statement. Regulatory packages (specification summaries, audit support) available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for pharmaceutical research and development use by licensed organisations only. It is not for direct human or veterinary administration, not for retail sale, and not for personal use. Mechanism statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
