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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：910463-68-2
- Createtime： 2026-11-05
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | White Powder |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C187H291N45O59 |
| Sample Available | Yes |
Semaglutide | CAS 910463-68-2 | GLP-1 Receptor Agonist | Knowlux
Product Description
Semaglutide, CAS 910463-68-2, is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist supplied by Knowlux. It is a synthetic 31-amino-acid peptide with a C-18 fatty acid side chain attached to Lys26, enabling albumin binding and a prolonged half-life of approximately 165 hours. The molecular formula is C187H291N45O59 and the molecular weight is 4113.64 g/mol. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Semaglutide |
| Synonyms | OG217SC; NN9535; Ozempic; |
| CAS No. | 910463-68-2 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.64 g/mol |
| Sequence Length | 31 amino acids, lipidated (C-18 fatty acid on Lys26) |
| Key Structural Features | Aib substitution at position 8; C-18 fatty diacid side chain on Lys26 |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥98.0% (HPLC); ≥99.0% available on request |
| Identity | Confirmed by LC-MS and peptide mapping |
| Grade | Research grade; GMP grade on request |
| Counter-ion | Acetate (lot-specific, declared on COA) |
| Moisture | ≤8.0% (Karl Fischer) |
| Endotoxin | ≤50 EU/mg |
| Storage | ?20 °C, protected from light and moisture; reconstituted solution 2–8 °C, use within 7 days |
| HS Code | 2937.19.00 (other polypeptide hormones and derivatives) |
| Packaging | 1 mg / 5 mg / 10 mg / 100 mg / 1 g vial; bulk and OEM on request |
| MOQ | 10 mg (research grade); 1 g (bulk) |
| Supply Ability | Gram to kilogram scale |
| Application | Pharmaceutical R&D and manufacturing |
| Origin | China |
Product Details
1. Overview
Semaglutide is a GLP-1 analogue developed as a longer-acting alternative to liraglutide, with structural modifications that extend its duration of action to approximately one week. Two key modifications distinguish it from native GLP-1: substitution of Ala8 with α-aminoisobutyric acid (Aib), which confers resistance to DPP-4 degradation, and attachment of a C-18 fatty diacid side chain to Lys26, which promotes albumin binding and reduces renal clearance. The peptide sequence is HXEGTFTSDV SSYLEGQAAK EFIAWLVRGR G, where X represents the Aib residue.
2. Mechanism of Action
Semaglutide binds the GLP-1 receptor on pancreatic β-cells and activates Gs-coupled cAMP signalling, producing glucose-dependent insulin secretion, suppression of glucagon release, slowing of gastric emptying, and reduced appetite through central GLP-1 signalling. The prolonged half-life of approximately 165 hours supports once-weekly subcutaneous administration in its commercial presentation. The molecule has been studied for glycaemic control in type 2 diabetes mellitus, as well as for weight management and cardiovascular risk reduction.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity / monomer | SEC-HPLC |
| Purity / related impurities | RP-HPLC |
| Identity & molecular mass | LC-MS (deconvoluted) |
| Primary structure | Peptide mapping / amino acid analysis |
| Aggregation & fragments | SEC-MALS (on request) |
| Glycosylation profile | SDS-PAGE / IEF (on request) |
| Endotoxin | LAL (kinetic turbidimetric) |
| Host cell protein / DNA | ELISA / qPCR |
| Moisture / appearance | Karl Fischer / visual |
| Sterility & bioburden | Membrane filtration (GMP grade) |
4. Applications
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Reference standard and impurity/aggregate studies for GLP-1 receptor agonist methods
-
GLP-1R binding, cAMP and β-cell functional assay development
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Formulation development for long-acting injectable peptides and Fc-fusion proteins
-
Biosimilarity and analog research, including glycoform and aggregation profiling
-
LC-MS, immunoassay and bioassay calibrators
5. Packaging, Storage & Shipping
Borosilicate glass vial with butyl stopper and aluminium seal, under inert gas where required; tamper-evident, light-protected carton with desiccant. Cold-chain 2–8 °C with validated gel packs and temperature logger; dry ice for ?20 °C shipments. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, GMO/allergen-free statement, residual solvent and elemental impurity statements, stability data summaries. Regulatory packages (DMF/CEP references, site information, audit support) available on a project basis.
Compliance Statement
This product is supplied for pharmaceutical research, development and manufacturing use by licensed organisations only. It is not for direct human or veterinary administration, not for retail sale, and not for personal use. Mechanism and clinical development statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
