Knowlux Urolithin A CAS 1143-70-0 from Chinese Manufacturer with safe shipment-Hubei Knowlux Biotechnology Co.,Ltd.

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Knowlux Urolithin A CAS 1143-70-0 from Chinese Manufacturer with safe shipment

Brand：Knowlux

Model：Bottle/Aluminum foil bag/Drum/Customized to your needs

Purity：99%+

Cas：1143-70-0

Createtime： 2026-11-03
Updatetime： 2026-11-03

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Product Details

useage	Nutraceutical, cosmetic, and life-science research applications
deliveryInfo
appearance	Off-white to light yellow or beige powder
aliasen
supplyCapacity	10MT/Month
Molecular formula	C13H8O4
harbor	Hongkong, Shenzhen, Shanghai
Sample available	Yes
minorder	1KG

Urolithin A (CAS 1143-70-0) — Product Description

Document scope: Bulk ingredient specification and compliance summary
Basis: Cross-referenced against GuideChem export white paper, TCI America, Sigma-Aldrich, PubChem, and China B2B platform listings. Discrepancies corrected.

1. Product Identity

Parameter	Verified Value
Product Name	Urolithin A
CAS RN	1143-70-0
Synonyms	3,8-Dihydroxy-6H-benzo[c]chromen-6-one; 3,8-Dihydroxyurolithin
Molecular Formula	C13H8O4
Molecular Weight	228.20 g/mol
MDL Number	MFCD20275235
HS Code	2932.20.4500

Correction note: Several marketplace listings describe Urolithin A as a “pomegranate peel extract.” Urolithin A is not present in meaningful quantities in raw pomegranate; it is a gut-microbial metabolite of ellagitannins (punicalagin, ellagic acid). Suppliers offering “pomegranate extract” should be asked to distinguish between natural-fermentation-derived material and chemically synthesized or biotransformation-derived Urolithin A. The production route affects regulatory positioning and impurity profile.

2. Key Quality Attributes

Attribute	Specification (Commercial Standard)
Appearance	Off-white to light yellow or beige powder
Assay (HPLC)	≥98% (food and cosmetic grade); ≥97% (research grade)
Identification	Confirmed by 1H NMR; LC-MS/MS deprotonated ion near m/z 227
Solubility	Soluble in DMSO (~20 mg/mL, clear); poorly soluble in water and low-polarity solvents
Storage	2–8°C, protected from light and moisture; heat-sensitive
Shelf Life	24 months under recommended storage

Critical quality warning: The GuideChem compliance white paper explicitly flags Urolithin A as a category subject to enforcement and litigation involving products with little or no active material. Buyers should require HPLC purity ≥98%, orthogonal confirmation by LC-MS/MS and proton NMR, plus residual solvent and elemental impurity data per ICH Q3C/Q3D. A certificate of analysis alone is insufficient without lot-linked analytical raw data.

3. Regulatory and Compliance Status

United States: FDA closed GRAS Notice No. 791 with a no-questions response in 2018 for defined food categories and use levels. Dietary supplement use must comply with 21 CFR Part 111 cGMP. Importers are subject to Foreign Supplier Verification Program (FSVP) requirements. Structure/function claims must avoid disease language.

European Union: Bulk ingredient placed on the EU market at ≥1 tonne/year is subject to REACH registration (EC) No 1907/2006 and CLP classification and labelling (EC) No 1272/2008. Cosmetic use requires safety assessment and CPNP notification under (EC) No 1223/2009. Suppliers should maintain separate documentation sets for chemical, food, and cosmetic channels; a single COA is not adequate across all three.

China (Export Context): Domestic suppliers typically position material as food-grade or cosmetic-grade. Export documentation should clearly state the intended use category; misalignment between the stated grade and the destination market’s regulatory pathway creates import risk.

4. Functional and Biological Profile

Urolithin A is the most extensively studied urolithin metabolite. Its primary reported mechanism is induction of mitophagy—the selective removal of dysfunctional mitochondria—demonstrated in vitro and in vivo following oral administration. Secondary reported activities include antioxidant and antiproliferative effects, and the compound has been shown to cross the blood-brain barrier in preclinical models.

Important positioning note: These are research and preclinical findings. Commercial product descriptions must not imply therapeutic efficacy for any disease indication. The ingredient is sold as a bulk raw material for further formulation, not as a drug.

5. Supply Chain and Packaging

Element	Recommendation
Primary Packaging	Foil inner bag with desiccant, sealed within HDPE drum or fiber carton
Barrier Requirement	Moisture and oxygen accelerate degradation; specify WVTR and closure integrity
Labelling	Product name, CAS, assay, batch, production route (where applicable), storage conditions, retest date
Traceability	Lot-to-production-record linkage; digitally resolvable identifiers support brand qualification and recall readiness
Documentation Package	COA with raw analytical data, SDS, production route statement, allergen and contaminant declarations

Marketplace discrepancy corrected: Alibaba and Made-in-China listings commonly state “99% purity” with “pomegranate peel extract” origin and “2-year shelf life at cool dry place.” The purity claims are plausible for commercial material, but the extraction-source framing is technically imprecise. The storage recommendation on B2B platforms (“cool dry place”) is less stringent than the 2–8°C recommendation from TCI and Sigma-Aldrich; for material intended for long-term inventory or formulation stability studies, refrigerated storage is preferred.

6. Purchasing Checklist

Confirm production route: chemical synthesis, biotransformation/fermentation, or natural extraction (if the latter, clarify substrate and purification).
Request lot-specific HPLC chromatogram with integration data, not just a reported percentage.
Verify orthogonal identity: LC-MS/MS and 1H NMR data for the lot.
Request residual solvent and elemental impurity data per ICH Q3C/Q3D.
Confirm regulatory dossier alignment with intended market and use category (food vs. cosmetic vs. research).
Check packaging barrier specification and stability data supporting the stated shelf life in the proposed packaging configuration.