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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：70288-86-7
- Createtime： 2026-11-03
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | White to off-white crystalline powder, slightly hygroscopic |
| aliasen | |
| supplyCapacity | 10MT/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1KG |
| Molecular Formula: | C48H74O14 (B1a component) |
| Sample Available | Yes |
Ivermectin | CAS 70288-86-7 | Antiparasitic Macrocyclic Lactone | Knowlux
Product Description
Ivermectin, CAS 70288-86-7, is a semi-synthetic macrocyclic lactone antiparasitic supplied by Knowlux. It is a mixture of two homologues, 22,23-dihydroavermectin B1a (≥90%) and 22,23-dihydroavermectin B1b (≤10%), derived from the fermentation products of Streptomyces avermitilis. Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Ivermectin |
| Synonyms | 22,23-Dihydroavermectin B1a/B1b; |
| CAS No. | 70288-86-7 |
| Molecular Formula | C48H74O14 (B1a component) |
| Molecular Weight | 875.09 g/mol |
| Composition | B1a ≥90%; B1b ≤10% |
| Appearance | White to off-white crystalline powder |
| Solubility | Insoluble in water; soluble in methanol, ethanol, chloroform |
| Purity | ≥95.0% (HPLC, B1a + B1b) |
| Identity | Confirmed by HPLC retention time and MS |
| Grade | Research grade; GMP grade on request |
| Storage | 2–8 °C, protected from light and moisture |
| HS Code | 2941.90.00 (other antibiotics) |
| Packaging | 1 g / 5 g / 10 g / 100 g / 1 kg; bulk and OEM on request |
| MOQ | 10 g (research grade); 1 kg (bulk) |
| Supply Ability | Gram to kilogram scale |
| Application | Pharmaceutical R&D and manufacturing |
| Origin | China |
1. Overview
Ivermectin is a macrocyclic lactone antiparasitic agent derived from avermectin B1. It is a mixture of two homologous components, with 22,23-dihydroavermectin B1a (C48H74O14) as the major constituent (≥90%) and B1b (C47H72O14) as the minor component (≤10%). It is widely used in pharmaceutical research and is the active ingredient in several approved human and veterinary antiparasitic products.
2. Mechanism of Action
Ivermectin acts by binding to glutamate-gated chloride channels (GluCl) in invertebrate nerve and muscle cells, increasing membrane permeability to chloride ions and causing hyperpolarisation, paralysis and death of susceptible parasites. In mammals, ivermectin does not readily cross the blood-brain barrier at therapeutic doses, which contributes to its wide safety margin. It is active against nematodes and arthropods, but not against cestodes or trematodes.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity (B1a + B1b) | HPLC |
| Component ratio (B1a/B1a+B1b) | HPLC |
| Identity | HPLC retention time / MS |
| Appearance | Visual |
| Loss on drying | Karl Fischer |
| Related substances | HPLC |
| Residual solvents | GC (on request) |
| Heavy metals | ICP-MS (on request) |
Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.
4. Applications
-
Reference standard and impurity studies for macrocyclic lactone antiparasitic methods
-
GluCl channel binding and functional assay development
-
Antiparasitic drug formulation research
-
Biosimilarity and analogue research
-
LC-MS and immunoassay calibrators
5. Packaging, Storage & Shipping
Primary packing: amber glass vial or aluminium foil bag, protected from light. Secondary packing: tamper-evident carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, GMO/allergen-free statement, residual solvent and elemental impurity statements. Regulatory packages (DMF references, site information, audit support) available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical res
earch compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for pharmaceutical research, development and manufacturing use by licensed organisations only. It is not for direct human or veterinary administration, not for retail sale, and not for personal use. Mechanism and clinical development statements are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance.
