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- Brand：Knowlux
- Model：Bottle/Aluminum foil bag/Drum/Customized to your needs
- Purity：99%
- Cas：616204-22-9
- Createtime： 2026-11-03
- Updatetime： 2026-11-03
| useage | medical intermediate，Pharmaceutical Intermediates |
| deliveryInfo | |
| appearance | white powder |
| aliasen | |
| supplyCapacity | 1T/Month |
| harbor | Hong Kong, Shanghai, Shenzhen |
| minorder | 1G |
| Molecular Formula: | C34H60N14O12S |
| Sample Available | Yes |
Acetyl Hexapeptide-8 (Acetyl Hexapeptide-3) | CAS 616204-22-9 | Cosmetic Peptide | Knowlux
Product Description
Acetyl Hexapeptide-8, CAS 616204-22-9, is a synthetic hexapeptide supplied by Knowlux for cosmetic research and formulation use. It is also known by its trade name Argireline and was formerly listed under the INCI name Acetyl Hexapeptide-3 before the nomenclature was updated to Acetyl Hexapeptide-8. The peptide sequence is Ac-Glu-Glu-Met-Gln-Arg-Arg-NH?, corresponding to molecular formula C34H60N14O12S and molecular weight 888.99 g/mol (free base). Each lot is released with a lot-specific COA, MSDS and full analytical traceability.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Acetyl Hexapeptide-8 |
| Synonyms | Acetyl Hexapeptide-3; Argireline; Acetyl Hexapeptide-8/3 |
| CAS No. | 616204-22-9 |
| Molecular Formula | C34H60N14O12S |
| Molecular Weight | 888.99 g/mol (free base) |
| Peptide Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH? |
| Appearance | White to off-white powder or clear solution |
| Purity | ≥95.0% (HPLC); ≥98.0% available on request |
| Identity | Confirmed by LC-MS and amino acid analysis |
| Grade | Cosmetic grade; research grade |
| Counter-ion | Acetate or TFA (lot-specific, declared on COA) |
| Moisture | ≤7.0% (Karl Fischer) |
| Storage | 2–8 °C (solution) or ?20 °C (lyophilized powder), protected from light and moisture |
| HS Code | 2937.90.00 (other polypeptide hormones and derivatives) |
| Packaging | 1 g / 5 g / 10 g / 100 g / 1 kg; bulk and OEM on request |
| MOQ | 10 g (research/cosmetic grade); 1 kg (bulk) |
| Supply Ability | Gram to kilogram scale |
| Application | Cosmetic R&D and formulation |
| Origin | China |
Product Details
1. Overview
Acetyl Hexapeptide-8 (Argireline) is a synthetic hexapeptide widely used as a cosmetic raw material in anti-aging formulations. It is a derivative of the N-terminal domain of SNAP-25 and is designed to modulate neurotransmitter release at the neuromuscular junction. The INCI name was officially changed from Acetyl Hexapeptide-3 to Acetyl Hexapeptide-8 in the 11th edition of the International Cosmetic Ingredient Dictionary (2006). Both names refer to the same CAS substance.
2. Mechanism of Action
Acetyl Hexapeptide-8 competes with SNAP-25 for binding sites within the SNARE complex, interfering with the assembly of the vesicle-fusion machinery. This reduces calcium-dependent exocytosis of neurotransmitters at the presynaptic membrane, leading to diminished contraction of facial muscles and a reduction in the formation of dynamic wrinkles. In vitro studies have demonstrated inhibition of SNARE complex formation and reduced catecholamine release from chromaffin cells. The peptide is considered approximately 4,000 times less toxic than botulinum toxin in comparative assessments.
3. Quality Control
| Test Item | Method |
|---|---|
| Purity | RP-HPLC |
| Identity & molecular mass | LC-MS (deconvoluted) |
| Amino acid composition | Amino acid analysis |
| Counter-ion content | Ion chromatography (TFA or acetate) |
| Moisture | Karl Fischer |
| Appearance | Visual |
| Heavy metals | ICP-MS (on request) |
| Microbial limits | ISO 17516 (on request) |
Full COA, MSDS, and lot-specific chromatograms are issued with each shipment. Custom specifications and third-party inspection can be arranged.
4. Applications
- Anti-wrinkle and anti-aging cosmetic formulations (emulsions, serums, eye creams, masks)
- Reference standard for cosmetic peptide analytical methods
- SNARE complex inhibition studies
- Neurotransmitter release assay development
- Cosmetic formulation stability and compatibility research
5. Packaging, Storage & Shipping
Lyophilized powder: amber glass vial under nitrogen headspace, sealed with butyl stopper and aluminium crimp. Solution grade: sealed amber glass or HDPE bottle. Secondary packing: tamper-evident, light-protected carton with desiccant. Ambient or cold-chain shipping with temperature logger where required. COA, MSDS, packing list and certificate of origin issued with each shipment.
6. Documentation Support
Per lot: COA, MSDS, certificate of origin, GMO/allergen-free statement, residual solvent statement. Regulatory packages (INCI documentation, specification summaries, audit support) available on a project basis.
About Knowlux
Knowlux Biotechnology is a GMP-oriented manufacturer and supplier of peptides, APIs and fine-chemical research compounds, operating from Hubei, China. We serve research groups, CDMOs and distributors in more than 40 countries, and support contract synthesis, custom packaging and technical documentation requests.
Compliance Statement
This product is supplied for cosmetic research and formulation use only. It is not for injection, not for pharmaceutical use, not for retail sale, and not for personal use. Statements describing mechanism are for scientific reference only and do not constitute medical advice, promotional claims, or dosing guidance. The INCI name Acetyl Hexapeptide-8 supersedes the older Acetyl Hexapeptide-3 designation; both refer to CAS 616204-22-9.
